論文

査読有り 国際誌
2016年

Gel-Trapped Lymphorganogenic Chemokines Trigger Artificial Tertiary Lymphoid Organs and Mount Adaptive Immune Responses In Vivo.

Frontiers in immunology
  • Yuka Kobayashi
  • ,
  • Takeshi Watanabe

7
開始ページ
316
終了ページ
316
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fimmu.2016.00316

We previously generated artificial lymph node-like tertiary lymphoid organs (artTLOs) in mice using lymphotoxin α-expressing stromal cells. Here, we show the construction of transplantable and functional artTLOs by applying soluble factors trapped in slow-releasing gels in the absence of lymphoid tissue organizer stromal cells. The resultant artTLOs were easily removable, transplantable, and were capable of attracting memory B and T cells. Importantly, artTLOs induced a powerful antigen-specific secondary immune response, which was particularly pronounced in immune-compromised hosts. Synthesis of functionally stable immune tissues/organs like those described here may be a first step to eventually develop immune system-based therapeutics. Although much needs to be learned from the precise mechanisms of action, they may offer ways in the future to reestablish immune functions to overcome hitherto untreatable diseases, including severe infection, cancer, autoimmune diseases, and various forms of immune deficiencies, including immune-senescence during aging.

リンク情報
DOI
https://doi.org/10.3389/fimmu.2016.00316
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27597851
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992816
ID情報
  • DOI : 10.3389/fimmu.2016.00316
  • PubMed ID : 27597851
  • PubMed Central 記事ID : PMC4992816

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