論文

査読有り 国際誌
2011年10月

Synthesis of functional artificial lymphoid tissues.

Discovery medicine
  • Yuka Kobayashi
  • ,
  • Koichi Kato
  • ,
  • Takeshi Watanabe

12
65
開始ページ
351
終了ページ
62
記述言語
英語
掲載種別
研究論文(学術雑誌)

The generation of functional artificial lymphoid tissue will be a major focus of future research. In humans, this will be an alternative tool which induces specific immune responses at ectopic sites and offers a novel way to restore the immune status and to treat uncontrollable obstinate diseases such as cancer, autoimmune diseases, severe infection, and immunodeficiency caused by primary defect or aging. Artificially synthesized lymphoid tissue may also provide us with a highly informative method to further study development and physiological functions of lymphoid tissues and organs. We recently reported successful generation of artificial lymph node-like tissues at ectopic sites in mouse. They showed a remarkable ability to induce secondary immune responses upon antigen stimulation, especially when transplanted into naïve or immunodeficient hosts. In this review, before discussing generation of synthetic immune systems, we first summarize previous knowledge on lymphoid development, which provides information valuable for making artificial lymphoid tissues such as spleen and lymph nodes. Then, we discuss problems that need to be solved in order to synthesize artificial lymphoid tissues, including several issues such as combinations of stromal cells, their cell types, soluble factors, and scaffold properties that enable proper accumulation and organization of immune cells in grafts.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22031672
ID情報
  • eISSN : 1944-7930
  • PubMed ID : 22031672

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