論文

査読有り 国際誌
2010年11月

Synthesis of artificial lymphoid tissue with immunological function.

Trends in immunology
  • Yuka Kobayashi
  • ,
  • Takeshi Watanabe

31
11
開始ページ
422
終了ページ
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.it.2010.09.002

The ability to generate functional artificial lymphoid tissue to induce specific immunity at ectopic sites could offer a potential breakthrough for treatment of diseases such as cancer and severe infection using immunotherapy. Artificial lymphoid tissue could also offer an informative tool to study further lymphoid tissue development and function in vivo. Here, we review the process of secondary and tertiary lymphoid organization, of which an understanding is essential for artificial lymphoid tissue synthesis. Using this knowledge, we consider the combination of cell types, soluble factors and scaffold properties that will enable proper accumulation and organization of lymphocytes into tissue grafts. Recent success in in vivo induction of artificial lymphoid tissue are also considered.

リンク情報
DOI
https://doi.org/10.1016/j.it.2010.09.002
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20951645
ID情報
  • DOI : 10.1016/j.it.2010.09.002
  • PubMed ID : 20951645

エクスポート
BibTeX RIS