論文

査読有り
2016年1月1日

Synthesis of functional tertiary lymphoid organs

Synthetic Immunology
  • Yuka Kobayashi
  • ,
  • Koichi Kato
  • ,
  • Makoto Nakamura
  • ,
  • Takeshi Watanabe

開始ページ
151
終了ページ
169
記述言語
英語
掲載種別
論文集(書籍)内論文
DOI
10.1007/978-4-431-56027-2_7
出版者・発行元
Springer Japan

The regeneration of functional immune organ will be one of major focus in future immunology research. It will be an useful tool which induces efficient immune responses in the body on demand and offers effective ways to restore the immune status and treat uncontrollable obstinate diseases such as cancer, autoimmune diseases, severe infection and immuno-insufficiency/deficiency caused by tissue damages, abnormality, primary defect and aging. Artificially synthesized lymphoid organs may also provide us with a highly informative method not only for clinical aim but also basic study on the development and functions of immunological tissues and organs. We first reported successful generation of artificiallyconstructed lymph node-like tertiary lymphoid tissues at ectopic sites in mouse by applying certain stromal cell lines (Suematsu S, Watanabe T. Nat Biotechnol 22 (12):1539-1545, 2004
Okamoto N et al. J Clin Invest 117(4):997-1007, 2007
Kobayashi Y, Watanabe T. Trends Immunol 31(11):422-428, 2010). They showed a remarkable ability to induce immune responses upon antigen stimulation, especially when transplanted into naïve or immune-compromised hosts. In this review, we discuss about the rationale and method for the synthesis of functional tertiary lymph node-like lymphoid tissues in mouse. Especially, we discuss here on the method with applying only soluble factors but without using any stromal cell, that enables proper accumulation and functional organization of immune cells in grafts.

リンク情報
DOI
https://doi.org/10.1007/978-4-431-56027-2_7
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018865410&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85018865410&origin=inward
ID情報
  • DOI : 10.1007/978-4-431-56027-2_7
  • SCOPUS ID : 85018865410

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