論文

国際誌
2016年6月

Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.

Nature neuroscience
  • Masaki Ueno
  • ,
  • Yuka Ueno-Nakamura
  • ,
  • Jesse Niehaus
  • ,
  • Phillip G Popovich
  • ,
  • Yutaka Yoshida

19
6
開始ページ
784
終了ページ
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/nn.4289

Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.

リンク情報
DOI
https://doi.org/10.1038/nn.4289
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27089020
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882232
ID情報
  • DOI : 10.1038/nn.4289
  • PubMed ID : 27089020
  • PubMed Central 記事ID : PMC4882232

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