2016年6月
Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
Nature neuroscience
- ,
- ,
- ,
- ,
- 巻
- 19
- 号
- 6
- 開始ページ
- 784
- 終了ページ
- 7
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/nn.4289
Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
- リンク情報
- ID情報
-
- DOI : 10.1038/nn.4289
- PubMed ID : 27089020
- PubMed Central 記事ID : PMC4882232