In this article, we develop attitude tracking control methods for spacecraft as rigid bodies against model uncertainties, external disturbances, subsystem faults/failures, and limited resources. A new intelligent control algorithm is proposed using approximations based on radial basis function neural networks (RBFNNs) and adopting the tunable parameter-based variable structure (TPVS) control techniques. By choosing different adaptation parameters elaborately, a series of control strategies are constructed to handle the challenging effects due to actuator faults/failures and input saturations. With the help of the Lyapunov theory, we show that our proposed methods guarantee both finite-time convergence and fault-tolerance capability of the closed-loop systems. Finally, benefits of the proposed control methods are illustrated through five numerical examples.