Apr, 2019 - Mar, 2021
Elucidation of antibacterial action mechanism of iron chelator as a basis of controlling oral biofilm
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
- Grant number
- 19K18961
- Japan Grant Number (JGN)
- JP19K18961
- Grant amount
-
- (Total)
- 4,290,000 Japanese Yen
- (Direct funding)
- 3,300,000 Japanese Yen
- (Indirect funding)
- 990,000 Japanese Yen
This study was aimed to evaluate the inhibitory effects of novel iron chelators, the super-polyphenols (SPs) which has different isoforms respectively, on oral bacteria.
We found that SP5, 6 and SP10 inhibited oral bacterial growth and the further examination revealed SP6 and SP10 suppressed biofilm formation of cariogenic Streptococcus mutans (Sm). Viability test on Sm indicated their effects to be bacteriostatic. These results suggest that SP6 and SP10 have the potential to control oral bacterial infections.
However, cytotoxicity to human gingival fibroblasts were observed even by the lowest effective concentration of SPs on bacteria.
We found that SP5, 6 and SP10 inhibited oral bacterial growth and the further examination revealed SP6 and SP10 suppressed biofilm formation of cariogenic Streptococcus mutans (Sm). Viability test on Sm indicated their effects to be bacteriostatic. These results suggest that SP6 and SP10 have the potential to control oral bacterial infections.
However, cytotoxicity to human gingival fibroblasts were observed even by the lowest effective concentration of SPs on bacteria.
- Link information
- ID information
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- Grant number : 19K18961
- Japan Grant Number (JGN) : JP19K18961