Yuki Kuwano

Profile Information

J-GLOBAL ID: 201801010347803891
researchmap Member ID: B000325377

Research Areas

Life sciences / Molecular biology /

Papers

circRNA: A New Biomarker and Therapeutic Target for Esophageal Cancer.

Katsutoshi Shoda, Yuki Kuwano, Daisuke Ichikawa, Kiyoshi Masuda

Biomedicines, 10(7), Jul 8, 2022
Multiple G-quadruplexes in the LMNA promoter regulate LMNA variant 6 transcription and promote colon cancer cell growth.

Tatsuya Nishikawa, Yuki Kuwano, Mayu Nakata, Kazuhito Rokutan, Kensei Nishida

Biochimica et biophysica acta. Gene regulatory mechanisms, 1864(10) 194746-194746, Oct, 2021
Overexpression of the transcribed ultraconserved region Uc.138 accelerates colon cancer progression.

Yuki Kuwano, Kensei Nishida, Kazuhito Rokutan

Scientific reports, 11(1) 8667-8667, Apr 21, 2021
The MicroRNA-23b/27b/24 Cluster Facilitates Colon Cancer Cell Migration by Targeting FOXP2.

Kensei Nishida, Yuki Kuwano, Kazuhito Rokutan

Cancers, 12(1), Jan 10, 2020
Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study.

Nishida K, Sawada D, Kuwano Y, Tanaka H, Rokutan K

Nutrients, 11(8), Aug, 2019 Peer-reviewed
HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells.

Nishikawa T, Kuwano Y, Takahara Y, Nishida K, Rokutan K

Scientific reports, 9(1) 10276, Jul, 2019 Peer-reviewed
Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: A double-blind, randomized, and placebo-controlled clinical trial

Daisuke Sawada, Yuki Kuwano, Hiroki Tanaka, Susumu Hara, Yoshihide Uchiyama, Tomonori Sugawara, Shigeru Fujiwara, Kazuhito Rokutan, Kensei Nishida

Journal of Functional Foods, 57 465-476, Jun 1, 2019
A novel long non-coding RNA from the HOXA6-HOXA5 locus facilitates colon cancer cell growth.

Saijo S, Kuwano Y, Tange S, Rokutan K, Nishida K

BMC cancer, 19(1) 532, Jun, 2019 Peer-reviewed
Research Paper ZNF350 promoter methylation accelerates colon cancer cell migration

Hiroki Tanaka, Yuki Kuwano, Tatsuya Nishikawa, Kazuhito Rokutan, Kensei Nishida

Oncotarget, 9 36750-36769, Dec 1, 2018
Diverse roles of RNA-binding proteins in cancer traits and their implications in gastrointestinal cancers.

Masuda K, Kuwano Y

Wiley interdisciplinary reviews. RNA, e1520, Nov, 2018 Peer-reviewed
Nucleolin facilitates nuclear retention of an ultraconserved region containing TRA2β4 and accelerates colon cancer cell growth

Yuzuru Satake, Yuki Kuwano, Tatsuya Nishikawa, Kinuyo Fujita, Saki Saijo, Miki Itai, Hiroki Tanaka, Kensei Nishida, Kazuhito Rokutan

Oncotarget, 9(42) 26817-26833, Jun 1, 2018 Peer-reviewed
Geranylgeranylacetone prevents stress-induced decline of leptin secretion in mice

Miki Itai, Yuki Kuwano, Tatsuya Nishikawa, Kazuhito Rokutan, Kensei Nishida

Journal of Medical Investigation, 65(1-2) 103-109, 2018 Peer-reviewed
Para-psychobiotic Lactobacillus gasseri CP2305 ameliorates stress-related symptoms and sleep quality

K. Nishida, D. Sawada, T. Kawai, Y. Kuwano, S. Fujiwara, K. Rokutan

JOURNAL OF APPLIED MICROBIOLOGY, 123(6) 1561-1570, Dec, 2017 Peer-reviewed
Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students

Kensei Nishida, Daisuke Sawada, Yuki Kuwano, Hiroki Tanaka, Tomonori Sugawara, Yumeko Aoki, Shigeru Fujiwara, Kazuhito Rokutan

JOURNAL OF FUNCTIONAL FOODS, 36 112-121, Sep, 2017 Peer-reviewed
RNA Binding Proteins and Genome Integrity

Kensei Nishida, Yuki Kuwano, Tatsuya Nishikawa, Kiyoshi Masuda, Kazuhito Rokutan

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(7), Jul, 2017 Peer-reviewed
Adverse parenting is associated with blunted salivary cortisol awakening response and altered expression of glucocorticoid receptor and 2-adrenergic receptor mRNAs in leukocytes in Japanese medical students

Tomoko Kawai, Yuki Kuwano, Kiyoshi Masuda, Kinuyo Fujita, Hiroki Tanaka, Tatsuya Nishikawa, Kazuhito Rokutan, Kensei Nishida

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 20(2) 159-166, Mar, 2017 Peer-reviewed
The effects of administration of the Lactobacillus gasseri strain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome

K. Nobutani, D. Sawada, S. Fujiwara, Y. Kuwano, K. Nishida, J. Nakayama, H. Kutsumi, T. Azuma, K. Rokutan

JOURNAL OF APPLIED MICROBIOLOGY, 122(1) 212-224, Jan, 2017 Peer-reviewed
Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial

M. Takada, K. Nishida, Y. Gondo, H. Kikuchi-Hayakawa, H. Ishikawa, K. Suda, M. Kawai, R. Hoshi, Y. Kuwano, K. Miyazaki …

BENEFICIAL MICROBES, 8(2) 153-162, 2017 Peer-reviewed
Negative perception of socioeconomic status with depressive mood down-regulates expression of PPBP and SLC1A7 genes in peripheral blood leukocytes

Kinuyo Fujita, Yuki Kuwano, Saki Saijo, Tatsuya Nishikawa, Kensei Nishida, Kazuhito Rokutan

Cogent Psychology, 4(1), Jan 1, 2017 Peer-reviewed
Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course

Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K

Journal of Functional Foods, 31 188-197, 2017 Peer-reviewed

Misc.

プロバイオティクスによる新しい健康長寿戦略脳腸相関を介した睡眠改善作用

西田憲生, 桑野由紀, 六反一仁

ストレス科学, 34(4) 230-239, Jun, 2020
大腸がん細胞に高発現する機能性RNA uc.138による大腸がん悪性化メカニズムの解明

桑野由紀, 西田憲生, 六反一仁

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
大腸がん細胞の遊走能獲得を制御するmicroRNAの探索

西田憲生, 田中裕基, 桑野由紀, 六反一仁

日本消化器病学会雑誌, 116(臨増大会) A817-A817, Nov, 2019
ストレスと腸内細菌叢乳酸菌を用いた新たな健康戦略

六反一仁, 桑野由紀, 西田憲生

ストレス科学, 33(4) 331-344, Jul, 2019
超保存領域を内在するT-UCRのRNAメチル化を介した大腸がん悪性化機構

桑野由紀, 西田憲生, 六反一仁

日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019
機能性RNA TRA2β4の核局在が誘導する大腸がん悪性化メカニズム

桑野由紀, 西川達哉, 西條早希, 西田憲生, 六反一仁

日本分子生物学会年会プログラム・要旨集(Web), 41st ROMBUNNO.2P‐0204 (WEB ONLY), 2018
microRNA23b/27b/24clusterを介した大腸がん細胞の形質転換制御機構

西田憲生, 田中裕基, 西條早希, 板井美樹, 藤田絹代, 西川達哉, 桑野由紀, 六反一仁

日本生化学会大会(Web), 90th ROMBUNNO.1P‐0408 (WEB ONLY), 2017
大腸がん細胞の遊走能獲得過程におけるDNAメチル化修飾の役割

田中裕基, 西田憲生, 西條早希, 板井美樹, 西川達哉, 桑野由紀, 六反一仁

日本生化学会大会(Web), 90th ROMBUNNO.2P‐0331 (WEB ONLY), 2017
hnRNP familyを介した超保存領域を内在するTRA2β4RNAの発現調節メカニズムの解明

西川達哉, 桑野由紀, 高原由実子, 西條早希, 田中裕基, 板井美樹, 西田憲生, 六反一仁

日本生化学会大会(Web), 90th ROMBUNNO.2P‐0673 (WEB ONLY), 2017
HOXA5遺伝子領域を含む新規転写産物の同定と機能解析

西條早希, 西田憲生, 桑野由紀, 六反一仁

日本生化学会大会(Web), 90th ROMBUNNO.2P‐0676 (WEB ONLY), 2017
TRA2β4のRNAメチル化を介した大腸癌悪性化の分子基盤

桑野由紀, 山中佐織, 西川達哉, 佐竹譲, 藤田絹代, 西條早希, 田中裕基, 西田憲生, 六反一仁

日本生化学会大会(Web), 90th ROMBUNNO.2P‐0670 (WEB ONLY), 2017
最新のストレスバイオマーカーと心理生理学的計測法末梢血の遺伝子発現解析によるストレスの評価

田中裕基, 桑野由紀, 西川達哉, 西田憲生, 六反一仁

ストレス科学, 30(4) 285‐289, Aug 31, 2016
医学用語解説 NMD

西田憲生, 桑野由紀, 西川達哉, 六反一仁

G.I. Research, 24(4) 290‐291, Aug 1, 2016
医学用語解説エピジェネティクス

西田憲生, 桑野由紀, 西川達哉, 六反一仁

G.I. Research, 24(4) 288‐289, Aug 1, 2016
心と身体のコミュニケーション~ストレス,不眠,抗うつ,ムードフード~腸に定着してストレスを緩和する乳酸菌

六反一仁, 西田憲生, 桑野由紀

Food Style 21, 20(6) 29‐31, Jun 1, 2016
精神科領域の用語解説第53回マイクロRNA

桑野由紀, 六反一仁

分子精神医学, 16(1) 45-46, Jan 10, 2016
Serine/arginine‐richスプライシング因子SRSFを介したエピジェネティック調節機構

桑野由紀, 西田憲生, 西川達哉, 六反一仁

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.3PS16‐7 (WEB ONLY), 2016
ストレスとエピジェネテイクス

Kensei Nishida, Yuki Kuwano, Takuya Naruto, Kazuhito Rokutan

産業精神保健, Vol.23(No.3) 234-238, Mar, 2015 Invited
【細胞とヒトの多様なストレス応答】ヒトのストレス応答ストレスバイオマーカーの同定と今後の展開

六反一仁, 桑野由紀, 西田憲生, 増田清士

Surgery Frontier, 20(4) 413-418, Dec, 2013
RNA結合蛋白質HuRによる選択的スプライシング制御機構の解明

増田清士, 赤池瑶子, 庄田勝俊, 村田知慧, 桑野由紀, 西田憲生, 田嶋敦, 井本逸勢

ストレス科学, 28(3) 203-203, Oct, 2013

Research Projects

RNA methylation of T-UCRs regulates colon cancer progression

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Mechanism of tumour heterogeneity mediated by mRNA processing

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

NISHIDA Kensei, TANAKA Hiroki, KUWANO Yuki, ROKUTAN Kazuhito

Industrial Property Rights

特許第6894097号腎性貧血改善用組成物

六反一仁, 西田憲生, 桑野由紀, 藤原茂, 菅原智詞, 青木ゆめこ, 澤田大輔
特許第6894096号軟骨再生促進用組成物

六反一仁, 西田憲生, 桑野由紀, 藤原茂, 菅原智詞, 青木ゆめこ, 澤田大輔
特許第6923883号栄養状態改善に使用するための組成物

六反一仁, 西田憲生, 桑野由紀, 藤原茂, 菅原智詞, 青木ゆめこ, 澤田大輔

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Research Projects

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