Yukihiko Sugimoto

J-GLOBAL         Last updated: Apr 11, 2019 at 19:29
 
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Name
Yukihiko Sugimoto
Affiliation
Kumamoto University

Research Areas

 
 

Academic & Professional Experience

 
Jan 2010
 - 
Today
Professor, Department of Pharmaceutical Biochemistry, Kumamoto University
 
Apr 2009
 - 
Jan 2010
Professor, Department of Pharmaceutical Biochemistry, Kumamoto University
 
2007
 - 
2009
Associate Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
 
Jun 2000
 - 
Jun 2001
Visiting Faculty, Department of Pharmacology, University of Pennsylvania
 

Published Papers

 
Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.
Tsuge, K., Inazumi, T., Shimamoto, A., and Sugimoto, Y.
Int. Immunol.   in press   2019   [Refereed]
Role of cyclooxygenase-2/prostaglandin E2/prostaglandin E receptor 4 signaling in cardiac reprogramming.
Muraoka, N., Nara, K., Tamura, F., Kojima, H. Yamakawa, H., Sadahiro, T., Miyamoto, K., Isomi, M., Haginiwa, S., Tani, H., Kurotsu, S., Osakabe, R., Torii, S., Shimizu, S., Okano, H., Sugimoto, Y., Fukuda, K., and Ieda, M.
Nature Commun.   10 674   2019   [Refereed]
Competition for mitogens regulates spermatogenic stem cell homeostasis in an open niche.
Kitadate, Y., Jörg, D.J., Tokue, M., Maruyama, A., Ichikawa, R., Tsuchiya, S., Segi-Nishida, E., Nakagawa, T., Uchida, A., Kimura-Yoshida, C., Mizuno, S., Sugiyama, F., Azami, T., Ema, M., Noda, C., Kobayashi, S., Matsuo, I., Kanai, Y., Nagasawa, T., Sugimoto, Y., Takahashi, S., *Simons, B.D., and *Yoshida, S.
Cell Stem Cell   24 79-92   2019   [Refereed]
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.
Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Yamashita, K., Hirata, K., Sekiguchi, Y., Yasuda, S., Shiroishi, M., Shimizu, T., Urushibata, Y., Kajiwara, Y., Inazumi, T., Hotta, Y., Asada, H., Nakane, T., Shiimura, Y., Nakagita, T., Tsuge, K., Yoshida, S., Kuribara, T., Hosoya, T., Sugimoto, Y., Nomura, N., Sato, M., Hirokawa, T., Kinoshita, M., Murata, T., Takayama, K., Yamamoto, M., Narumiya, S., Iwata, S., and Kobayashi, T.
Nature Chem. Biol.   15 18-26   2019   [Refereed]
Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation.
Matsumoto, R., Dainichi, T., Tsuchiya, S., Nomura, T., Kitoh, A., Hayden, M.S., Ishii, K.J., Tanaka, M., Honda, T., Egawa, G., Otsuka,A., Nakajima, S., Sakurai, K., Nakano, Y., Kobayashi, T., Sugimoto, Y., and Kabashima, K.
JCI Insight.   3 e121175   2018   [Refereed]
Cross-talk between prostaglandin and retinoic acid signaling.
Inazumi, T., and Sugimoto, Y.
Carotenoid Science   in press   2018   [Refereed][Invited]
Yano A, Takahashi Y, Moriguchi H, Inazumi T, Koga T, Otaka A, Sugimoto Y
Biochimica et biophysica acta   1862(6) 615-622   2017   [Refereed]
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N
Cancer discovery   7 522-538   2017   [Refereed]
Aikawa, S., Kano, K., Inoue, A., Wang, J., Saigusa, D., Nagamatsu, K., Hirota, Y., Fujii, T., Tsuchiya, S., Taketomi, Y., Sugimoto, Y., Murakami, M., Arita, M., Kurano, M., Ikeda, H., Yatomi, Y., Chun, J., and Aoki, J.
EMBO J.   36 2146-2160   2017   [Refereed]
Kato, H., Kai, A., Kawabata, T., Sunderhaus, J.D., McAfoos, T.J., Finefield, J.M., Sugimoto, Y., Williams, R.M., and Tsukamoto, S.
Bioorg. Med. Chem. Lett.   27 4975-4978   2017   [Refereed]
Yabuki Y, Koide T, Miyasaka N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y, Yoshihara Y
Nature neuroscience   19(7) 897-904   2016   [Refereed]
Tsuchiya H, Hohjoh H, Fujiwara Y, Sugimoto Y, Koshimizu TA
Biochemical and biophysical research communications   470(4) 804-810   2016   [Refereed]
告恭史郎, 杉本幸彦
医学のあゆみ   256(5) 561-566   2016
Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C
The Journal of biological chemistry   290(50) 29781-29793   2015   [Refereed]
Ikeda, K., Tomimoto, S., Tsuchiya, S., Hamagami, K., Shintani, N., Sugimoto, Y., Ichikawa, A., Kasai, A., Nakazawa, T., Nagayasu, K., Hayata-Takano, A., Baba, A., Hashimoto, H.
Biochem. Biophys. Rep.   2 179-183   2015   [Refereed]
Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimoto H
Biochemical and biophysical research communications   461(4) 612-617   2015   [Refereed]
Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K
The Journal of investigative dermatology   135(4) 1007-1015   2015   [Refereed]
Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
Biochimica et biophysica acta   1851(4) 414-421   2015   [Refereed]
Sugimoto Y, Inazumi T, Tsuchiya S
Journal of biochemistry   157(2) 73-80   2015   [Refereed]
SUGIMOTO YUKIHIKO
月刊臨床免疫・アレルギー科   63(1) 62-67   2015
杉本幸彦
日本薬理学雑誌   145(5) 237-242 (J-STAGE)   2015
Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
Biochimie   107 78-81   Dec 2014   [Refereed]
Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K
Nature immunology   15(11) 1064-1069   Nov 2014   [Refereed]
Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   28(9) 4036-4043   Sep 2014   [Refereed]
Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T
The Journal of experimental medicine   211(6) 1063-1078   Jun 2014   [Refereed]
HOJO HIROFUMI, SUGIMOTO YUKIHIKO
医学のあゆみ   248(13) 977-983   Mar 2014
Morimoto K, Shirata N, Taketomi Y, Tsuchiya S, Segi-Nishida E, Inazumi T, Kabashima K, Tanaka S, Murakami M, Narumiya S, Sugimoto Y
Journal of immunology (Baltimore, Md. : 1950)   192(3) 1130-1137   Feb 2014   [Refereed]
Yokoyama U, Minamisawa S, Shioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, Ishikawa Y
Circulation   129(4) 487-496   Jan 2014   [Refereed]
Nakazawa S, Sakanaka M, Furuta K, Natsuhara M, Takano H, Tsuchiya S, Okuno Y, Ohtsu H, Nishibori M, Thurmond RL, Hirasawa N, Nakayama K, Ichikawa A, Sugimoto Y, Tanaka S
European journal of immunology   44(1) 204-214   Jan 2014   [Refereed]
Kawahara K, Suenobu M, Ohtsuka H, Kuniyasu A, Sugimoto Y, Nakagomi M, Fukasawa H, Shudo K, Nakayama H
Journal of Alzheimer's disease : JAD   42(2) 587-605   2014   [Refereed]
Sakaida M, Sukeno M, Imoto Y, Tsuchiya S, Sugimoto Y, Okuno Y, Segi-Nishida E
Journal of psychopharmacology (Oxford, England)   27(11) 1058-1069   Nov 2013   [Refereed]
Toda T, Homma D, Tokuoka H, Hayakawa I, Sugimoto Y, Ichinose H, Kawasaki H
Developmental cell   27(1) 32-46   Oct 2013   [Refereed]
Iwasaki R, Tsuge K, Morimoto K, Inazumi T, Kawahara O, Kawahara A, Tsuchiya S, Sugimoto Y
Biochemical and biophysical research communications   438(2) 353-358   Aug 2013   [Refereed]
Segi-Nishida E, Sukeno M, Imoto Y, Kira T, Sakaida M, Tsuchiya S, Sugimoto Y, Okuno Y
Neuropharmacology   71 164-173   Aug 2013   [Refereed]
Tsuge K, Iwasaki R, Morimoto K, Inazumi T, Kawahara O, Kawahara A, Tsuchiya S, Sugimoto Y
Biochemical and biophysical research communications   436(4) 685-690   Jul 2013   [Refereed]
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M
Nature immunology   14(6) 554-563   Jun 2013   [Refereed]
INAZUMI TOMOAKI, TSUCHIYA SOKEN, SUGIMOTO YUKIHIKO
遺伝子医学MOOK   24(24) 187-192   May 2013
Naoki Nakagawa, Naoki Nakagawa, Koh Ichi Yuhki, Koh Ichi Yuhki, Jun Ichi Kawabe, Takayuki Fujino, Takayuki Fujino, Osamu Takahata, Maki Kabara, Kazutoshi Abe, Fumiaki Kojima, Fumiaki Kojima, Hitoshi Kashiwagi, Hitoshi Kashiwagi, Naoyuki Hasebe, Kenjiro Kikuchi, Yukihiko Sugimoto, Shuh Narumiya, Shuh Narumiya, Fumitaka Ushikubi, Fumitaka Ushikubi
Kidney International   82 158-171   Jul 2012
Inflammatory responses in the kidney lead to tubulointerstitial fibrosis, a common feature of chronic kidney diseases. Here we examined the role of prostaglandin E2 (PGE2) in the development of tubulointerstitial fibrosis. In the kidneys of wild-t...
SUGIMOTO YUKIHIKO, MORIMOTO KAZUSHI
月刊臨床免疫・アレルギー科   57 386-390   May 2012
K. Kawahara, K. Kawahara, M. Suenobu, M. Suenobu, A. Yoshida, K. Koga, A. Hyodo, H. Ohtsuka, H. Ohtsuka, A. Kuniyasu, A. Kuniyasu, N. Tamamaki, Y. Sugimoto, H. Nakayama
Neuroscience   207 243-260   Apr 2012
We previously reported that the anti-inflammatory cytokine interleukin (IL)-4 induced selective clearance of oligomeric β-amyloid (Aβ1-42) in rat primary type 2 microglial cells. For the present study, we investigated whether IL-4 and IL-13 could ...
Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T
Journal of neurochemistry   120(5) 795-805   Mar 2012   [Refereed]
Yokoyama U, Ishiwata R, Jin MH, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y
PloS one   7(5) e36724   2012   [Refereed]
Morimoto K, Tsuchiya S, Sugimoto Y
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   132(11) 1217-1223   2012   [Refereed]
Takano H, Furuta K, Yamashita K, Sakanaka M, Itano N, Gohda E, Nakayama K, Kimata K, Sugimoto Y, Ichikawa A, Tanaka S
Biological & pharmaceutical bulletin   35(3) 408-412   2012   [Refereed]
SUGIMOTO YUKIHIKO
ファルマシア   47(12) 1114-1116   Dec 2011
Inazumi T, Shirata N, Morimoto K, Takano H, Segi-Nishida E, Sugimoto Y
Journal of lipid research   52(8) 1500-1508   Aug 2011   [Refereed]
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K
Endocrinology   151(12) 5893-5904   Dec 2010   [Refereed]
Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T, Hayashi I, Sugimoto Y, Narumiya S, Saigenji K, Majima M
American journal of physiology. Gastrointestinal and liver physiology   299(5) G1078-86   Nov 2010   [Refereed]

Conference Activities & Talks

 
Prostaglandin E2 regulates physiological lipid storage status.
Yukihiko Sugimoto
The 15th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases. (Puerto Vallarta, Mexico)   25 Oct 2017   
Regulation of adipocyte functions by the prostaglandin EP4 receptor. [Invited]
Yukihiko Sugimoto
International Conference on Lipoquality. (Tokyo)   22 Sep 2017   
PGE2-EP3 receptor signaling induces inflammatory swelling by mast cell activation.
Yukihiko Sugimoto
PSK-PSJ joint-international symposium in 2016   18 Oct 2016   
Roles of prostaglandin EP4 receptor in adipose tissue.
Yukihiko Sugimoto, Tomoaki Inazumi, Soken Tsuchiya, Shuh Narumiya
The 7th International conference on phospholipase A2 and Lipid Mediators(PLM2016)   19 May 2016   
Towards structure determination of the human prostanoid receptor bound to the antibody.
Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, Yusuke Sekiguchi, Keitaro Yamashita, Kunio Hirata, Satoshi Yasuda, Hidetsugu Asada, Takanori Nakane, Yuki Shiimura, Tomoya Nakagita, Tomoaki Inazumi, Kyoshiro Tsuge, Yuta Kajiwara, Tomoko Shimizu, Yuji Urushibata, Suguru Yoshida, Tomoko Kuribara, Takamitsu Hosoya, Masahiro Kinoshita, Yukihiko Sugimoto, Norimichi Nomura, Takeshi Murata, Kiyoshi Takayama, Masaki Yamamoto, Shuh Narumiya, So Iwata, Takuya Kobayashi
GPCR Workshop 2015   1 Dec 2015   
Prostanoid receptor signaling is involved in vasculogenesis during early developmental stage of zebrafish.
Iwasaki, R., Tsuge, K., Inazumi, T., Kawahara, A., Tsuchiya, S., Sugimoto, Y.
International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)   16 Oct 2015   
Prostaglandin E2 contributes lipid homeostasis in adipose tissue.
Inazumi, T., Tsuchiya, S., Narumiya, S., Sugimoto, Y.
International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)   16 Oct 2015   
Prostanoid receptor signaling is involved in vasculogenesis during early development of zebrafish.
Iwasaki, R., Tsuge, K., Inazumi, T., Kawahara, A., Tsuchiya, S., Sugimoto, Y.
The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases   15 Jul 2015   
Roles of prostaglandin E2 in acute inflammation of skin.
Sugimoto, Y., Tsuchiya, S., Inazumi, T., Narumiya, S.
The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases   15 Jul 2015   
The role of prostanoid receptors in vasculogenesis of zebrafish
Ryo Iwasaki, Kyoshiro Tsuge, Tomoaki Inazumi, Atsuo Kawahara, Soken Tsuchiya, Yukihiko Sugimoto
6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)   10 Feb 2015   
The roles of prostanoid receptors during somite stages of zebrafish development
Kyoshiro Tsuge, Ryo Iwasaki, Koichiro Kishimoto, Tomoaki Inazumi, Atsuo Kawahara, Soken Tsuchiya, Yukihiko Sugimoto
6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)   10 Feb 2015   
Physiological regulation of adipocyte function by prostaglandin E2.
Tomoaki Inazumi, Soken Tsuchiya, Shuh Narumiya, Yukihiko Sugimoto
6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)   10 Feb 2015   
Prostaglandin E2 facilitates neurite outgrowth in preoptic neurons
Hirofumi Hohjoh, Miki Yoshioka, Hiroyoshi Tsuchiya, Soken Tsuchiya, Shogo Misumi, Segi-Nishida Eri, Yukihiko Sugimoto
6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)   10 Feb 2015   
The role of multiple prostanoid receptors in embryo implantation and spacing
Soken Tsuchiya, Xiaoyan Ma, Kimaru Okubo, Tomoaki Inazumi, Toshiko Sugimoto, Yuka Horikoshi, Toru Takeo, Naomi Nakagata, Shuh Narumiya, Yukihiko Sugimoto
6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)   10 Feb 2015   
Prostaglandin E2–EP3 signaling triggers mast cell activation and acute inflammation. [Invited]
Yukihiko Sugimoto
10 Feb 2015   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2011 - 2013    Investigator(s): Yukihiko SUGIMOTO
In this study, by focusing on dermal mast cells (MCs), we tried to identify functional changes in association with transition to lymph node, and to understand molecular mechanism underlying MC maturation and activation driven by prostaglandins (PG...