Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.
Tsuge, K., Inazumi, T., Shimamoto, A., and Sugimoto, Y.
Int. Immunol. in press 2019 [Refereed]
Role of cyclooxygenase-2/prostaglandin E2/prostaglandin E receptor 4 signaling in cardiac reprogramming.
Muraoka, N., Nara, K., Tamura, F., Kojima, H. Yamakawa, H., Sadahiro, T., Miyamoto, K., Isomi, M., Haginiwa, S., Tani, H., Kurotsu, S., Osakabe, R., Torii, S., Shimizu, S., Okano, H., Sugimoto, Y., Fukuda, K., and Ieda, M.
Nature Commun. 10 674 2019 [Refereed]
Competition for mitogens regulates spermatogenic stem cell homeostasis in an open niche.
Kitadate, Y., Jörg, D.J., Tokue, M., Maruyama, A., Ichikawa, R., Tsuchiya, S., Segi-Nishida, E., Nakagawa, T., Uchida, A., Kimura-Yoshida, C., Mizuno, S., Sugiyama, F., Azami, T., Ema, M., Noda, C., Kobayashi, S., Matsuo, I., Kanai, Y., Nagasawa, T., Sugimoto, Y., Takahashi, S., *Simons, B.D., and *Yoshida, S.
Cell Stem Cell 24 79-92 2019 [Refereed]
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.
Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Yamashita, K., Hirata, K., Sekiguchi, Y., Yasuda, S., Shiroishi, M., Shimizu, T., Urushibata, Y., Kajiwara, Y., Inazumi, T., Hotta, Y., Asada, H., Nakane, T., Shiimura, Y., Nakagita, T., Tsuge, K., Yoshida, S., Kuribara, T., Hosoya, T., Sugimoto, Y., Nomura, N., Sato, M., Hirokawa, T., Kinoshita, M., Murata, T., Takayama, K., Yamamoto, M., Narumiya, S., Iwata, S., and Kobayashi, T.
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N
Aikawa, S., Kano, K., Inoue, A., Wang, J., Saigusa, D., Nagamatsu, K., Hirota, Y., Fujii, T., Tsuchiya, S., Taketomi, Y., Sugimoto, Y., Murakami, M., Arita, M., Kurano, M., Ikeda, H., Yatomi, Y., Chun, J., and Aoki, J.
Ikeda, K., Tomimoto, S., Tsuchiya, S., Hamagami, K., Shintani, N., Sugimoto, Y., Ichikawa, A., Kasai, A., Nakazawa, T., Nagayasu, K., Hayata-Takano, A., Baba, A., Hashimoto, H.
Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimoto H
Biochemical and biophysical research communications 461(4) 612-617 2015 [Refereed]
Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K
The Journal of investigative dermatology 135(4) 1007-1015 2015 [Refereed]
Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K
Nature immunology 15(11) 1064-1069 Nov 2014 [Refereed]
Nakazawa S, Sakanaka M, Furuta K, Natsuhara M, Takano H, Tsuchiya S, Okuno Y, Ohtsu H, Nishibori M, Thurmond RL, Hirasawa N, Nakayama K, Ichikawa A, Sugimoto Y, Tanaka S
European journal of immunology 44(1) 204-214 Jan 2014 [Refereed]
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M
Nature immunology 14(6) 554-563 Jun 2013 [Refereed]
Inflammatory responses in the kidney lead to tubulointerstitial fibrosis, a common feature of chronic kidney diseases. Here we examined the role of prostaglandin E2 (PGE2) in the development of tubulointerstitial fibrosis. In the kidneys of wild-t...
K. Kawahara, K. Kawahara, M. Suenobu, M. Suenobu, A. Yoshida, K. Koga, A. Hyodo, H. Ohtsuka, H. Ohtsuka, A. Kuniyasu, A. Kuniyasu, N. Tamamaki, Y. Sugimoto, H. Nakayama
Neuroscience 207 243-260 Apr 2012
We previously reported that the anti-inflammatory cytokine interleukin (IL)-4 induced selective clearance of oligomeric β-amyloid (Aβ1-42) in rat primary type 2 microglial cells. For the present study, we investigated whether IL-4 and IL-13 could ...
Yokoyama U, Ishiwata R, Jin MH, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K
Endocrinology 151(12) 5893-5904 Dec 2010 [Refereed]
In this study, by focusing on dermal mast cells (MCs), we tried to identify functional changes in association with transition to lymph node, and to understand molecular mechanism underlying MC maturation and activation driven by prostaglandins (PG...
