論文

査読有り 国際誌
2018年9月

Mycobacterium heckeshornense lung infection diagnosed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • Akira Yokoyama
  • ,
  • Hidenori Kage
  • ,
  • Yuki Ohama
  • ,
  • Tomoaki Sato
  • ,
  • Naoya Miyashita
  • ,
  • Satoshi Noguchi
  • ,
  • Shu Okugawa
  • ,
  • Yasuhiro Yamauchi
  • ,
  • Kyoji Moriya
  • ,
  • Takahide Nagase

24
9
開始ページ
763
終了ページ
765
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jiac.2018.01.017

Identification of microorganisms by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been widely accepted. However, the significance of MALDI-TOF MS for identifying mycobacteria, particularly rare nontuberculous mycobacteria, has not been established. M. heckeshornense is one such bacteria, and distinguishing it from M. xenopi is difficult. The patient was a 40-year-old man with Behҫet's disease who had started treatment with prednisolone and azathioprine. A lung nodule in the right lower lobe was pointed out, and it increased in size 6 months later. Bronchoscopy was performed, and was culture positive for mycobacteria. It was identified as M. heckeshornense by MALDI-TOF MS with a score value of 1.928. Analysis of the 16S rRNA, rpoB, and hsp65 genes confirmed the result of MALDI-TOF MS. MALDI-TOF MS seems reliable for the diagnosis of M. heckeshornense infection.

リンク情報
DOI
https://doi.org/10.1016/j.jiac.2018.01.017
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29503226
ID情報
  • DOI : 10.1016/j.jiac.2018.01.017
  • ISSN : 1341-321X
  • PubMed ID : 29503226

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