2005年7月
Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: Disruption by cocaine sensitization
NEURON
- ,
- 巻
- 47
- 号
- 2
- 開始ページ
- 255
- 終了ページ
- 266
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2005.06.017
- 出版者・発行元
- CELL PRESS
The prefrontal cortex and the hippocampus exhibit converging projections to the nucleus accumbens and have functional reciprocal connections via indirect pathways. As a result, information processing between these structures is likely to be bidirectional. Using evoked potential measures, we examined the interactions of these inputs on synaptic plasticity within the accumbens. Our results show that the direction of information flow between the prefrontal cortex and limbic structures determines the synaptic plasticity that these inputs exhibit within the accumbens. Moreover, this synaptic plasticity at hippocampal and prefrontal inputs selectively involves dopamine D1 and D2 activation or inactivation, respectively. Repeated cocaine administration disrupted this synaptic plasticity at hippocampal and prefrontal cortical inputs and goal-directed behavior in the spatial maze task. Thus, interactions of limbic-prefrontal cortical synaptic plasticity and its dysfunction within the accumbens could underlie complex information processing deficits observed in individuals following psychostimulant administration.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.neuron.2005.06.017
- ISSN : 0896-6273
- Web of Science ID : WOS:000230693900012