Polymers of glucose, the most abundant and one of the biologically important natural products, named glucans are widely present in fungi, bacteria, mammals, and plants with various anomeric configurations and glycosidic linkages. Because of their structural diversity, the unified strategy for the assembly of pure glucans is yet to be developed. Herein, we describe a general strategy that is applicable to construction of all types of glucans by exploiting a bimodal glycosyl donor equipped with C2-o-TsNHbenzyl ether (TAB), which enables stereocontrolled synthesis of both α- and β-glycosides by switching reaction conditions.