2017年1月
Raman Spectroscopy of Pharmaceutical Cocrystals in Nanosized Pores of Mesoporous Silica
ANALYTICAL SCIENCES
- ,
- ,
- 巻
- 33
- 号
- 1
- 開始ページ
- 47
- 終了ページ
- 52
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2116/analsci.33.47
- 出版者・発行元
- JAPAN SOC ANALYTICAL CHEMISTRY
The Raman spectroscopy of pharmaceutical cocrystals based on caffeine and oxalic acid in nanosized pores of mesoporous silica has been demonstrated at various molar amounts. The Raman peak shifts of caffeine molecules express the existence of pharmaceutical cocrystals in mesoporous silica. The molar amount dependence of the peak shifts describes that caffeine and oxalic acid cocrystallized on the surface of the nanosized pores and piled up layer by layer. This is the first report that shows the Raman spectroscopy is a powerful tool to observe the synthesis of pharmaceutical cocrystals incorporated in the nanosized pores of mesoporous silica. The results indicate a way to control the size of cocrystals on a nanometer scale, which will provide higher bioavailability of pharmaceuticals.
- リンク情報
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- DOI
- https://doi.org/10.2116/analsci.33.47
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28070074
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000392910200010&DestApp=WOS_CPL
- URL
- http://orcid.org/0000-0002-4044-7347
- ID情報
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- DOI : 10.2116/analsci.33.47
- ISSN : 0910-6340
- eISSN : 1348-2246
- ORCIDのPut Code : 51519363
- PubMed ID : 28070074
- Web of Science ID : WOS:000392910200010