論文

国際誌
2011年9月

Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus.

Rheumatology (Oxford, England)
  • Takahisa Gono
  • ,
  • Yasushi Kawaguchi
  • ,
  • Hirotaka Kaneko
  • ,
  • Katsuji Nishimura
  • ,
  • Masanori Hanaoka
  • ,
  • Sayuri Kataoka
  • ,
  • Yuko Okamoto
  • ,
  • Yasuhiro Katsumata
  • ,
  • Hisashi Yamanaka

50
9
開始ページ
1578
終了ページ
85
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/rheumatology/keq408

OBJECTIVE: The aim of this study is to establish a detection method for anti-N-methyl-d-aspartate receptor subunit 2A (NR2A) antibody and to evaluate the relationship between anti-NR2A antibody and various organ involvement in SLE. METHODS: Serum anti-NR2A antibody was measured by ELISA using a peptide with a core of either DWEYS or DWDYS as autoantigen. Additionally, clinical characteristics were compared between 27 anti-NR2A antibody-positive (P group) and 80 antibody-negative (N group) SLE patients using DWDYS peptide. RESULTS: The optical density (OD) values of anti-NR2A antibody using DWDYS and DWEYS peptides correlated significantly (r = 0.94, P < 0.0001). The median OD value was significantly higher (P < 0.0001) with DWDYS. Additionally, the SLEDAI was significantly higher (P = 0.023) in the P group. The frequency of neuropsychiatric SLE (NPSLE) was significantly higher (P = 0.0002) in the P group, although the frequencies of serositis and nephritis were not statistically significant. Significant correlations were found between anti-NR2A antibody and leucocyte count (r(s) = -0.31, P = 0.001) and haemoglobin (r(s) = -0.42, P < 0.0001), although no correlation was found between anti-NR2A antibody and the titre of anti-dsDNA antibody. NPSLE was the most significant independent variable (P = 0.0008) associated with anti-NR2A antibody positivity, as estimated by multiple linear regression analysis. CONCLUSION: Serum anti-NR2A antibody can be associated with the complication of NPSLE and may indicate the involvement of non-nervous tissue. The use of peptides that include DWDYS is preferable to detect anti-NR2A antibody in ELISA.

リンク情報
DOI
https://doi.org/10.1093/rheumatology/keq408
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21208977
ID情報
  • DOI : 10.1093/rheumatology/keq408
  • PubMed ID : 21208977

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