論文

国際誌
2010年10月

Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease.

Rheumatology (Oxford, England)
  • Takahisa Gono
  • ,
  • Yasushi Kawaguchi
  • ,
  • Tomoko Sugiura
  • ,
  • Hisae Ichida
  • ,
  • Kae Takagi
  • ,
  • Yasuhiro Katsumata
  • ,
  • Masanori Hanaoka
  • ,
  • Yuko Okamoto
  • ,
  • Yuko Ota
  • ,
  • Hisashi Yamanaka

49
10
開始ページ
1878
終了ページ
81
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/rheumatology/keq196

OBJECTIVE: To determine whether IL-18 is involved in the inflammation of DM and PM. METHODS: Thirty-three patients with DM were enrolled in this study, including 25 with interstitial lung disease (ILD). In addition, 16 patients with PM were enrolled, including 6 with ILD. All patients were admitted to our hospital as a result of their condition requiring treatment, and clinical laboratory data including serum IL-18 were recorded on admission. RESULTS: Serum IL-18 was significantly (P < 0.0001) higher in both DM and PM patients than in healthy controls (n = 30). Serum ferritin and IL-18 were significantly (P = 0.003 and 0.0044, respectively) higher in DM than in PM patients. Additionally, ferritin and IL-18 were significantly (P = 0.023 and 0.034, respectively) higher in DM patients with ILD than in DM patients without ILD. Significant positive correlations were found between creatine kinase (CK) and ferritin (r(s) = 0.39, P = 0.024); CK and IL-18 (r(s) = 0.48, P = 0.005); and IL-18 and ferritin (r(s) = 0.54, P = 0.0012) in the DM group as a whole. These findings were different for the DM plus ILD subgroup: significant positive correlations were found between CK and ferritin (r(s) = 0.40, P = 0.047); CK and IL-18 (r(s) = 0.63, P = 0.0008); and IL-18 and ferritin (r(s) = 0.41, P = 0.042). CONCLUSION: Serum IL-18 was strikingly elevated in patients with DM and was associated particularly with disease activity and ILD complication in DM.

リンク情報
DOI
https://doi.org/10.1093/rheumatology/keq196
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20601655
ID情報
  • DOI : 10.1093/rheumatology/keq196
  • PubMed ID : 20601655

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