Yukio Morimoto

Profile Information

Affiliation: Professor,Professor, Research Reactor Institute, Research Reactor Institute Division of Quantum Beam Material Science, Kyoto University

Degree: Doctor of Science(Osaka University)
Master of Engineering(Tottori University)

Researcher number: 80200450
ORCID ID: https://orcid.org/0000-0003-1919-6309
J-GLOBAL ID: 200901086195416184
researchmap Member ID: 1000214816

External link: http://www-j.rri.kyoto-u.ac.jp/

Research Interests

Research Areas

Life sciences / Structural biochemistry /

Research History

1996 - 2003

Himeji Institute of Technology
1996 - 2003

Himeji Institute of Technology
1991 - 1996

Faculty of Engineering, The University of Tokushima
1991 - 1996

The University of Tokushima,
1987 - 1991

Himeji Institute of Technology
1987 - 1991

Himeji Institute of Technology,
Associate Professor
Research Assistant

Education

- 1987

Osaka University
- 1987

Graduate School, Division of Natural Science, Osaka University
- 1981

Faculty of Engineering, Tottori University
- 1981

Faculty of Engineering, Tottori University

Papers

188

Large-scale column-free purification of bovine F-ATP synthase

Chimari Jiko, Yukio Morimoto, Tomitake Tsukihara, Christoph Gerle

Journal of Biological Chemistry, 300(2) 105603-105603, Feb, 2024
Hydrogen/Deuterium Exchange Behavior During Denaturing/Refolding Processes Determined in Tetragonal Hen Egg-White Lysozyme Crystals

Y. Morimoto

Mol Biotechnol., Jan, 2022 Peer-reviewed
Dynamic interactions in the l-lactate oxidase active site facilitate substrate binding at pH4.5

Naoki Furubayashi, Koji Inaka, Masayuki Kamo, Yasufumi Umena, Takeshi Matsuoka, Yukio Morimoto

Biochemical and Biophysical Research Communications, 568 131-135, Sep, 2021 Peer-reviewedCorresponding author
Crystal structure analysis of the 20S proteasome grown in space: Comparison between space and ground crystals

Y. Morimoto, M. Kamo, N. Furubayashi, Y. Higashino, K. Inaka

Int. J. Microgravity Sci. Appl, 37 370404-1-370404-6, Oct, 2020 Peer-reviewed
構造研究における宇宙・微小重力環境の利用―高精度抗がん剤開発のために―

森本幸生, 加茂昌之, 古林直樹, 東野ゆうき, 伊中浩治

放射線生物研究, 55 197-209, Sep, 2020 Peer-reviewedLead author
Hydrogen/deuterium exchange behavior in tetragonal hen egg-white lysozyme crystals affected by solution state

Akiko Kita, Yukio Morimoto

Journal of Applied Crystallography, 53(3) 837-840, Jun 1, 2020 Peer-reviewed
Organomercury Captured by Lyase Overexpressed <i>Escherichia coli</i> and Its Evaluation by <i>In-Cell</i> Radiometry*

Yukio Morimoto, Koichi Takamiya

Advances in Enzyme Research, 08(02) 19-26, 2020
Six tris(bipyridyl)iron(II) complexes with 2-substituted 1,1,3,3-tetracyanopropenide, perchlorate and tetrafluoridoborate anions; order versus disorder, hydrogen bonding and C—N...π interactions

Abderezak Addala, Zouaoui Setifi, Yukio Morimoto, Be, n } }at Artetxe, Takashi Matsumoto, Juan M. Guti{\'{e } }rrez-Zorrilla, Christopher Glidewell

Acta Crystallographica Section E Crystallographic Communications, 74(12) 1717, Dec, 2018 Peer-reviewed
Preparation of F1Fo-ATP Synthase as a Whole Body Complex from Bovine Heart for Structural Analaysis by Cryo-electron Microscopy and X-ray Crystallography

C.Jiko, A.Uehara, C.Gerle, Y.Morimoto

KURRI Progress Report 2017, 176, Mar, 2018
Studies on the Binding Mechanism and Stoichiometry of Mercury Atoms in an Organomercury Lyase from Smeared Solution by an in-cell Radioactivation Analysis

K.Takamiya, Y.Morimoto

KURRI Progress Report 2017, 159, Mar, 2018
Complex structure of Irons Coordinated with Hydrophillic Polymer 18. Application for Mataric Plating on Resin Surface (2).

A.Kawaguchi, Y.Morimoto

KURRI Progress Report 2017, 134, Mar, 2018
Crystal structure of octocoral lectin SLL-2 complexed with Forssman antigen tetrasaccharide

Akiko Kita, Mitsuru Jimbo, Ryuichi Sakai, Yukio Morimoto, Ryota Takeuchi, Hiroshi Tanaka, Takashi Takahashi, Kunio Miki

GLYCOBIOLOGY, 27(8) 696-700, Aug, 2017 Peer-reviewed
Inhibitory effects of local anesthetics on the proteasome and their biological actions

Udin Bahrudin, Masaki Unno, Kazuya Nishio, Akiko Kita, Peili Li, Masaru Kato, Masashi Inoue, Shunichi Tsujitani, Takuto Murakami, Rina Sugiyama …

SCIENTIFIC REPORTS, 7(1), Jul, 2017 Peer-reviewed
Complex Structure of Ions Coordinated with Hydrophilic Polymer. 17. Inner Precipitation of Inorganic Salt as Fillers and Their Dissolution.

KURRI Progress report 2016, Mar, 2017 Peer-reviewed
Evaluation of molecular perturbation of a deuterated protein by temperature factor refinement in X-ray structural analysis of high-resolution diffraction data

T. Uemura, A. Kita, Y. Morimoto

J.Biotech.Biomat., Oct, 2016 Peer-reviewed
Structural Insight Into Protein Binding of Boron Tracedrug UTX-97 Revealed by the Co-Crystal Structure With Lysozyme at 1.26 angstrom Resolution

Yukio Morimoto, Hideko Nagasawa, Yoshihiro Uto, Toshiyuki Chatake, Hitoshi Hori

JOURNAL OF PHARMACEUTICAL SCIENCES, 105(8) 2298-2301, Aug, 2016 Peer-reviewed
Structural Insights of the Degradation Scheme of Yeast 20S Proteasome Studied by Genetic Mutation and AFM Motion Imaging

KURRI Progress report 2015, Mar, 2016 Peer-reviewed
Complex Structure of Ions Coordinated with Hydrophilic Polymer. 1 6. Application for Metaric Plating on Resin Surface . (1)

KURRI Pogress report 2015, Mar, 2016 Peer-reviewed
An Effective Deuterium Exchange Method for Neutron Crystal Structure Analysis with Unfolding-Refolding Processes

Akiko Kita, Yukio Morimoto

MOLECULAR BIOTECHNOLOGY, 58(2) 130-136, Feb, 2016 Peer-reviewed
The catalytic mechanism of decarboxylative hydroxylation of salicylate hydroxylase revealed by crystal structure analysis at 2.5 angstrom resolution

Takuya Uemura, Akiko Kita, Yoshihiko Watanabe, Motoyasu Adachi, Ryota Kuroki, Yukio Morimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469(2) 158-163, Jan, 2016 Peer-reviewed

Misc.

148

Hydrogen/deuterium exchange behavior in tetragonal hen egg-white lysozyme crystals affected by solution state

Akiko Kita, Yukio Morimoto

Journal of Applied Crystallography, 53(3) 837-840, Jun 1, 2020 Peer-reviewed
Structural analysis of ligand binding mechanism of L-lactate oxidase from Aerococcus viridans by use of ligand soaking crystals

Y. Morimoto, N. Furubayashi, M. Kamo, Y. Umena, A. Kita, T. Matsuoka, K. Inaka

16th Conference of the Asian Crystallographic Association (AsCA2019), Dec, 2019
重水内変性/再生試料に対するコントロールとしての，ニワトリ卵白リゾチームの中性子線結晶構造

喜田昭子, 森本幸生

日本結晶学会令和元年（2019年)度年会および総会, Nov, 2019
Hydrogen/deuterium exchange behavior in tetragonal hen egg-white lysozyme crystals analyzed by the neutron diffraction methods

A. Kita, Y. Morimoto

International Symposium on Diffraction Structural Biology 2019, Oct, 2019
Elucidation of protein denaturation with neutron crystallography

KITA Akiko, MORIMOTO Yukio

Jun, 2019
The neutron structure analysis of the protein crystal deuterated with unfolding-refolding processes

Akiko Kita, Yukio Morimoto

AsCA2018/CRYSTAL32, Dec, 2018
Fibrinolysis and disease prevention effects of nattokinase

Food style 21, 22(11) 43-47, Nov, 2018
Neutron diffraction studies of the protein crystal deuterated with unfolding-refolding processes

Akiko Kita, Yukio Morimoto

Annual Meeting 2018 and General Assembly, Crystallographic Society of Japan, Nov, 2018
Boron Tracedrugs: Drug-Design Challenge For Neutron Dynamic Therapy

Hitoshi Hori, Takumichi Sugihara, Takuya Tashiro, Hiroshi Terada, Ryota Takeuchi, Nobuyuki Kamegawa, Yukio Morimoto

Int.Cong.Neutron Capture Therapy, Oct, 2018 Peer-reviewed
４液混合液体クロマトグラフィーポンプを用いた各種濃度溶液の作成

森本幸生

JASCO Report, Jul, 2018 Invited
有機水銀分解酵素の中性子解析のための最小培地試料作成と構造解析

森本幸生, 喜田昭子

京都大学原子炉実験所学術講演会, Jan, 2018
変性重水素化リゾチームの中性子結晶構造解析

喜田昭子, 森本幸生

日本中性子科学会第１７回年会, Dec, 2017
哺乳動物のミトコンドリアFoF1ATP合成酵素完全複合体の精製

慈幸千真理, 森本幸生, Christoph Gerle

日本生体エネルギー研究会第43回討論会, Dec, 2017 Peer-reviewed
変性状態を利用した重水素化タンパク質結晶の中性子線回折実験の試み

喜田昭子, 森本幸生

日本結晶学会年会, Oct, 2017
サンゴ由来レクチン４糖複合体の結晶構造

喜田昭子, 神保充, 酒井隆一, 森本幸生, 武内良太, 田中浩士, 高橋孝志, 三木邦夫

京都大学原子炉実験所第５１回学術講演会, Jan, 2017
Crystal structure of symbiosis related lectin SLL-2 in complex with tetrasaccharides

A. Kita, M. Jimbo, R. Sakai, Y. Morimoto, R. Takeuchi, H. Tanaka, T. Takahashi, K. Miki

14th Conf. Asian Crystallographic Association, Dec, 2016 Peer-reviewed
共生に関与する珊瑚由来レクチンの４糖糖鎖結合様式

喜田昭子, 神保充, 酒井隆一, 森本幸生, 武内良太, 田中浩士, 高橋孝志, 三木邦夫

日本結晶学会年会, 2016, Nov, 2016
プロテアソームを弱く阻害する臨床薬の阻害機構について

杉山里奈, 山口宏, 森本幸生, 久留一郎, 海野昌喜

日本生化学会大会プログラム・講演要旨集, 89回 [1T11-06(1P, Sep, 2016
An effective deuterium exchange method for a neutron structure analysis by use of unfolding-refolding processes

A.Kita, Y.Morimoto

Int.Nat.Symp.Diff.Strct.Biol., Aug, 2016 Peer-reviewed
カテコール産生における脱炭酸・水酸基付加反応機構の考察 ―サリチル酸水酸化酵素の結晶構造解析からー

上村拓也, 喜田昭子, 安達, 黒木, 森本幸生

京都大学原子炉実験所第５０回学術講演会, Jan, 2016

Books and Other Publications

巨大なタンパク分解酵素複合体の特異な立体構造と機能相関

森本幸生

https://humans-in-space.jaxa.jp/kibouser/pickout/72801.html, Apr, 2021
日本の結晶学ＩＩ

森本幸生 (Role: Contributor, ヘモグロビン)

日本結晶学会, Oct, 2014
入門講座中性子科学への招待

神山崇, 森本幸生 (Role: Joint author)

Mar, 2006
ナノバイオ辞典（分担執筆）

森本幸生

フジテクノシステム, 2006
An Introduction to the Neutron Science

T. Kamiyama, Y. Morimoto

J. Cryst. Soc. Jpn, 2006
極限状態を見る放射光アナリシス（尾嶋正治編、分担執筆）日本分光学会測定法シリーズ

森本幸生

学会出版センター, 2001
SYNCHROTRON RADIATION IN THE BIOSCIENCES (jointly worked)

森本幸生

Oxford University Press.,, 1994

Presentations

高塩濃度下で形成されるDNA と二価金属の直接的相互作用

日本結晶学会2010年会
生体プロトン解析用中性子回折計の計画

日本中性子科学会2009年会
納豆菌培養液由来ナットウキナーゼの精製と結晶化

日本結晶学会2009年会
温度制御によるDNAの結晶化

日本結晶成長学会2009年会
Neutron crystallographic analysis revealed details of DNA binding protein DsrD

8th Korea-Japan meeting on Neutron Science
Spring-8における蛋白質科学研究の将来展望

第１回Spring-8ユーザーズミーティング
タンパク質結晶構造解析の実際—放射光でできること、放射光でするべきことー

ＳＰｒｉｎｇ８夏の学校
タンパク質の立体構造—放射光でできること、放射光でするべきことー

むつ小川原地域における放射光施設整備研究会（日本原子力産業会議）

Professional Memberships

Research Projects

Single particle cryoEM of mammalian FoF1 ATP synthase

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Gerle Christoph
Studies on the molecular behavior of the 26S proteasome by a low resolution structure analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MORIMOTO Yukio
Mechanism of abnormal protein aggregation and the study of the repair enzyme.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2012

FUJII Noriko, SUGIYAMA Masaaki, MORIMOTO Yukio, KINOUCHI Tadatoshi, SAITO Takeshi, SADAKANE Yutaka, KAJI Yuichi, SASAKI Horoshi, GOTO Yuji
Analysis for Dynamics on High Order Structure of Protein

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

SUGIYAMA Masaaki, KATO Koichi, MORIMOTO Yukio
Crystallographic and Molecular Studies on Yeast 26S Proteasome

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

MORIMOTO Yukio, NISHIO Kazuya, SUGIYAMA Masaaki
牛脾臓プロテアソームおよびユビキチン関連酵素システムの複合体構造研究

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

森本幸生
Structural studies on antigen presents system based on the 20S bovine proteasome.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2004

MORIMOTO Yukio
High Resolution X-ray Study of Cofactor Dependent Enzyme and Biocatalyst Design

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2001 - 2003

HIROTSU Ken, MORIMOTO Yukio, MIYAHARA Ikuko
牛肝臓20Sプロテアソームの2.5Å分解能結晶構造解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2001 - 2002

森本幸生
14-3-3/MSF蛋白における選択的シグナルあるいはペプチド認識機構の解明

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 2001 - 2001

森本幸生
牛肝臓20Sプロテアソームの高分解能結晶構造解析

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 1999 - 2000

森本幸生
Structural analysis of Proteasome activator from Bovine liver

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 2000

MORIMOTO Yukio
Structure Study of Vitamin B12 enzyme, Diol Dehydratase

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1998

YASUOKA Noritake, SHIBATA Naoki, MORIMOTO Yukio
ミトコンドリア蛋白質輸入因子MSFのX線解析による構造生物学的研究

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1997 - 1997

森本幸生
牛肝臓プロテアソームおよびその活性化因子の構造生物学的研究

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1997 - 1997

森本幸生
Trp合成酵素βサブユニットのX線解析による複合体形成原理の解明

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1997 - 1997

森本幸生
MSF/14-3-3蛋白質及びその標的蛋白質との複合体の構造解析

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1997 - 1997

三原勝芳, 森本幸生, 阪口雅郎
Crystal Structure Analysis of Bovine 20S Proteasome at High Resolution.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1995 - 1997

MORIMOTO Yukio, TANAKA Keiji
Research for Image Processing in Protein Crystallography

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1995 - 1997

MORIMOTO Yukio
プロテアソームの分子様態・結晶構造と機能解析に関する研究

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1996 - 1996

森本幸生, 田中啓二

Industrial Property Rights

特開特許第4314364号スクリーニング用溶液の作製方法及び装置

森本幸生, 阿部真琴, 鈴木雅洋, 梅名泰史

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