Yukino Machida

Profile Information

Affiliation: Nippon Veterinary and Life Science University

Degree: 医学博士(東京大学)

J-GLOBAL ID: 201801017057584511
researchmap Member ID: B000300687

Papers

Disseminated granulomatous encephalitis caused by Schizophyllum commune in a dog with severe neurological signs.

Tomokazu Nagashima, Shohei Tsumoto, Daisuke Yazawa, Miki Omura, Kazuhiko Ochiai, Karin Yoshida, Kayoko Sugibayashi, Yukino Machida, Ryoichi Suzuki, Koh Igarashi …

Journal of comparative pathology, 213 73-77, Aug, 2024 Peer-reviewed
Prostatic stromal tumour of uncertain malignant potential in a dog

Tomokazu Nagashima, Masanori Kobayashi, Yoshiaki Kubo, Katsuya Nagaho, Kayoko Sugibayashi, Takahiro Saito, Yukino Machida, Masaki Michishita

Journal of Comparative Pathology, 210 8-14, Apr, 2024 Peer-reviewed
Epithelioid leiomyosarcoma arising from the ocular region in a dog.

Tomokazu Nagashima, Chisato Kishi, Yukino Machida, Masaki Michishita

Veterinary research forum : an international quarterly journal, 15(5) 257-260, 2024 Peer-reviewed
Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia.

Ayuna Hattori, Emi Takamatsu-Ichihara, Yoshiki Yamamoto, Shuhei Fujita, Kazutsune Yamagata, Takuo Katsumoto, Yukino Machida, Haruka Shinohara, Ryo Murakami, Issay Kitabayashi

Leukemia, Jul 25, 2023 Peer-reviewed
Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts

Toshio Imai, Hiroshi Yoshida, Yukino Machida, Mizuki Kuramochi, Hitoshi Ichikawa, Takashi Kubo, Mami Takahashi, Tomoyasu Kato

Scientific Reports, 13(1), May 25, 2023 Peer-reviewed
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.

Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, Yukino Machida, Keitaro Shibata, Norihito Shintani, Takashi Kohno, Noriko Gotoh, Chiaki Takahashi, Atsushi Hirao …

Cell death & disease, 14(4) 241-241, Apr 5, 2023 Peer-reviewed
Pulmonary solid adenocarcinoma in a dog

Masaki Michishita, Naoki Hanari, Hitomi Oda, Tomokazu Nagashima, Yukino Machida, Yuji Hamamoto, Kyoichi Tamura, Daigo Azakami, Kazuhiko Ochiai, Akihiro Mori

Journal of Comparative Pathology, 201 100-104, Feb, 2023 Peer-reviewed
Infective endocarditis with systemic bacterial embolism caused by Staphylococcus aureus in a free-ranging Amami rabbit (Pentalagus furnessi)

Masaki Konnai, Masami Yamamoto, Keiko Ito, Hanae Yamabe, Takuya E Kishimoto, Hiroshi Aoki, Yukino Machida, Masaki Michishita, Makoto Haritani, Hisashi Yoshimura

Journal of Comparative Pathology, 201 23-27, Feb, 2023 Peer-reviewed
mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma

Masaki Michishita, Kazuhiko Ochiai, Rei Nakahira, Daigo Azakami, Yukino Machida, Tomokazu Nagashima, Takayuki Nakagawa, Toshiyuki Ishiwata

Frontiers in Oncology, 13, Jan 27, 2023 Peer-reviewed
Intrahepatic eosinophilic proliferative phlebitis in Japanese black cattle indicate allergies involving mast cell tryptase-dependent activation

Masaki Konnai, Kimimasa Takahashi, Yukino Machida, Masaki Michishita, Kozo Ohkusu-Tsukada

Frontiers in Veterinary Science, 9, Dec 20, 2022 Peer-reviewed
Feeding a High-Fat Diet for a Limited Duration Increases Cancer Incidence in a Breast Cancer Model

Toshio Imai, Mie Naruse, Yukino Machida, Gen Fujii, Michihiro Mutoh, Masako Ochiai, Mami Takahashi, Hitoshi Nakagama

Nutrition and Cancer, 1-13, Oct 20, 2022 Peer-reviewed
Adenomatous Hyperplasia of Bowman's Capsule Epithelium in a Dog with Metastatic Nasal and Hepatic Neuroendocrine Carcinoma

Yukino Machida, Marika Higo, So Doge, Tomokazu Nagashima, Takuya E. Kishimoto, Hisashi Yoshimura, Masami Yamamoto, Kazuki Okada, Naoko Yayoshi, Hitoshi Hatakeyama …

Journal of Comparative Pathology, 197 19-22, Sep, 2022 Peer-reviewedLead authorCorresponding author
Clinical usefulness of 2-hydroxyglutarate as a biomarker in IDH-mutant chondrosarcoma

Makoto Nakagawa, Masayuki Yamaguchi, Makoto Endo, Yukino Machida, Ayuna Hattori, Fumie Tanzawa, Shinji Tsutsumi, Issay Kitabayashi, Akira Kawai, Fumihiko Nakatani

Journal of Bone Oncology, 34 100430-100430, Jun, 2022 Peer-reviewed
Clinical examination and necropsy findings of a mountain hawk-eagle (<i>Nisaetus nipalensis</i>) that died during rehabilitation

Nana USHINE, Masaki MICHISHITA, Yukino MACHIDA, Tatsuya ENOMOTO, Takaaki SAKAI, Takuya KATO, Shin-ichi HAYAMA

Journal of Veterinary Medical Science, 2022 Peer-reviewed
Primary pulmonary diffuse large B-cell lymphoma associated with feline leukaemia virus infection in a young cat

Kento Ishikawa, Tomokazu Nagashima, Yukino Machida, Akiko Yasuda, Karin Yoshida, Michio Fujita, Kazuhiko Ochiai, Daigo Azakami, Masaki Michishita

Journal of Feline Medicine and Surgery Open Reports, 8(1) 205511692210742-205511692210742, Jan, 2022 Peer-reviewed
The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis

Yasuto Takeuchi, Natsuko Kimura, Takahiko Murayama, Yukino Machida, Daisuke Iejima, Tatsunori Nishimura, Minoru Terashima, Yuming Wang, Mengjiao Li, Reiko Sakamoto …

Proceedings of the National Academy of Sciences, 118(43) e2103658118-e2103658118, Oct 26, 2021 Peer-reviewed
Subleukaemic T-Lymphoblastic Leukaemia in a Horse

Masaki Michishita, Ritsu Shibata, Yukino Machida, Manami Matsumoto, Kazuhiko Ochiai, Daigo Azakami

Journal of Comparative Pathology, 188 21-25, Oct, 2021 Peer-reviewed
Different properties of mammary carcinogenesis induced by two chemical carcinogens, DMBA and PhIP, in heterozygous BALB/c Trp53 knockout mice

Yukino Machida, Toshio Imai

Oncology Letters, 22(4), Aug 16, 2021 Peer-reviewedLead author
Gastric Plasmacytoma with Immunoglobulin Lambda Light Chain Deposition in a Dog

Naoki Hanari, Tomokazu Nagashima, Yukino Machida, Yoshiaki Kubo, Yuji Hamamoto, Junichi Kamiie, Kazuhiko Ochiai, Daigo Azakami, Masaki Michishita

Journal of Comparative Pathology, 187 7-10, Aug, 2021 Peer-reviewed
Involvement of Nestin in the Progression of Canine Mammary Carcinoma.

Hisashi Yoshimura, Maiko Moriya, Ayaka Yoshida, Masami Yamamoto, Yukino Machida, Kazuhiko Ochiai, Masaki Michishita, Takayuki Nakagawa, Yoko Matsuda, Kimimasa Takahashi …

Veterinary pathology, 58(5) 3009858211018656-3009858211018656, May 31, 2021 Peer-reviewed

Misc.

犬の乳癌における葉酸代謝酵素MTHFD2の経路阻害による抗腫瘍効果

小名木れみ花, 町田雪乃, 落合和彦, 中川貴之, 道下正貴

日本獣医学会学術集会講演要旨集, 165回 [B2P-05], Sep, 2022
Targeting driver mutations and critical factors in hematological and solid cancers

Issay Kitabayashi, Yukiko Aikawa, Kazutsune Yamagata, Takuo Katsumoto, Yutaka Shima, Akihiko Yokoyama, Yukino Machida, Haruka Shinohara, Yoko Ogawara, Shuhei Fujita …

CANCER SCIENCE, 113 1256-1256, Feb, 2022
FRS2b fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis

Yasuto Takeuchi, Natsuko Kimura, Takahiko Murayama, Yukino Machida, Daisuke Iejima, Tatsunori Nishimura, Yuming Wang, Mizuki Yamamoto, Naoki Itano, Junichiro Inoue …

CANCER SCIENCE, 113 994-994, Feb, 2022
犬の乳腺腫瘍オルガノイドの樹立

柴田律, 町田雪乃, 榎本竜也, 木下那由多, 道下荘, 羽成直己, 呰上大吾, 落合和彦, 道下正貴

日本獣医学会学術集会講演要旨集, 164回 [BO-42], Sep, 2021
猫乳癌細胞株におけるCDK4/6阻害剤Palbociclibのin vitro抗腫瘍効果

遠藤美咲, 落合和彦, 町田雪乃, 呰上大吾, 中川貴之, 道下正貴

日本獣医学会学術集会講演要旨集, 164回 [BO-41], Sep, 2021
ドライバー変異と必須因子を標的とした分子標的治療法の開発を目指して

北林一生, 相川祐規子, 山形和恒, 勝本拓夫, 島豊, 横山明彦, 町田雪乃, 篠原悠, 小川原陽子, 藤田修平 …

日本癌学会学術総会抄録集(Web), 80th, 2021
猫の膵外分泌腺癌株化細胞Fpacc-E由来のsphere形成細胞の特性解析

兵頭あかね, 町田雪乃, 落合和彦, 落合和彦, 小野沢栄里, 呰上大吾, 道下正貴, 道下正貴

日本獣医学会学術集会講演要旨集, 164th (CD-ROM), 2021
犬の乳腺腫瘍におけるnestinの発現と悪性挙動への関与

吉村久志, 山本昌美, 岸本拓也, 岸本拓也, 町田雪乃, 道下正貴, 落合和彦, 中川貴之, 松田陽子, 高橋公正 …

日本獣医学会学術集会講演要旨集, 164th (CD-ROM), 2021
Gastrointestinal Stromal Tumor in a Pig

73(11) 665-668, Nov, 2020
犬の肺腺癌におけるヒトWHO分類に準拠した亜型分類および予後との関連性

高木香奈, 呰上大吾, 町田雪乃, 落合和彦, 道下正貴

日本獣医学会学術集会講演要旨集, 162回 347-347, Aug, 2019
犬のリンパ腫におけるPKM2発現と臨床病理学的および病理組織学的特徴との関連性

高添夏希, 町田雪乃, 野上英, 原田知享, 落合和彦, 呰上大吾, 道下正貴

日本獣医学会学術集会講演要旨集, 162回 348-348, Aug, 2019
進行性軟骨肉腫に対するIDH1変異阻害剤の新規治療の可能性

中川亮, 中谷文彦, 吉田朗彦, 小川原陽子, 藤田修平, 相川祐規子, 町田雪乃, 関剛彦, 岩本幸英, 北林一生

日本癌学会総会記事, 75回 J-2039, Oct, 2016
The mutant IDH1 inhibitor prevents growth of glioblastoma with IDH1 mutation in patient derived xenograft (PDX) model

Yukino Machida, Yoko Ogawara, Koichi Ichimura, Hironori Matsunaga, Seki Takahiko, Kazushi Araki, Issay Kitabayashi

CANCER RESEARCH, 76, Jul, 2016
Critical roles of FRS2beta, a feedback inhibitor of ErbB-ERK signaling, for communication between cancer stem cells and their niche during mammary tumorigenesis

Yukino Machida, Natsuko Kimura, Arinobu Tojo, Ko-ichi Akashi, Hideyuki Saya, Issay Kitabayashi, Noriko Gotoh

CANCER RESEARCH, 76, Jul, 2016
変異型IDH1阻害によるグリオーマに対する新規治療法の開発

町田雪乃, 小川原陽子, 山口雅之, 山形和恒, 相川祐規子, 中川亮, 松永大典, 関剛彦, サンペトラオルテア, 佐谷秀行 …

日本脳腫瘍学会学術集会プログラム・抄録集, 34th, 2016
The Role of IDH Mutants, Which Are Promising Therapeutic Targets for Acute Myeloid Leukemia

Yoko Ogawara, Hironori Matsunaga, Takahiko Seki, Yukino Machida, Kazushi Araki, Issay Kitabayashi

BLOOD, 126(23), Dec, 2015
IDH mutations are promising targets for acute myeloid leukemia

Yoko Ogawara, Hironori Matsunaga, Takahiko Seki, Yukino Machida, Kazushi Araki, Issay Kitabayashi

CANCER RESEARCH, 75, Aug, 2015

Presentations

IN VITRO DRUG SCREENING USING ORGANOID CULTURE DERIVED FROM CANINE LUNG CANCER FOR PRECISION MEDICINE

Yukino Machida, Yuna Ishizaki, So Doge, Kazuhiko Ochiai, Daigo Azakami, Masaki Michishita

2023, ACVP/ASVCP Annual Meeting, Oct 31, 2023
オルガノイド培養を基盤としたイヌのがん研究の有用性

町田雪乃

第166回日本獣医学会学術集会, Sep 6, 2023 Invited
BALB/c-p53 ＋/－マウスにおけるDMBAまたはPhIP誘発性乳がんの遺伝子変異/表現型の比較解析

町田雪乃, 須藤柚稀子, 打屋尚章, 落合雅子, 今井俊夫

第34回日本毒性病理学会学術集会, Jan 25, 2018
変異型IDH1阻害によるグリオーマに対する新規治療法の開発

町田雪乃, 小川原陽子, 山口雅之, 山形和恒, 相川祐規子, 中川亮, 松永大典, 関剛彦, サンペトラオルテア, 佐谷秀行, 市村幸一, 荒木一司, 北林一生

第34回日本脳腫瘍学会学術集会, Dec 5, 2016
変異型IDH1阻害剤は変異型IDH1を有する膠芽腫患者組織片皮下移植（PDX）モデルの腫瘍増殖を抑制する

町田雪乃, 小川原陽子, 山口雅之, 山形和恒, 相川祐規子, 中川亮, 松永大典, 関剛彦, サンペトラオルテア, 佐谷秀行, 市村幸一, 荒木一司, 北林一生

第75回日本癌学会学術集会, Oct 6, 2016 Invited
変異型IDH1を標的としたがん治療法

町田雪乃, 小川原陽子, 山口雅之, 山形和恒, 相川祐規子, 中川亮, 松永大典, 関剛彦, サンペトラオルテア, 佐谷秀行, 市村幸一, 荒木一司, 北林一生

第4回がんと代謝研究会, Jul 8, 2016 Invited
エストロジェン産生を伴う悪性奇形腫の猫の1例

町田雪乃, 道下正貴, 和田美帆, 塚田晃三, 高橋公正

第152回日本獣医学会学術集会, Sep 21, 2011

Teaching Experience

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獣医病理学実習
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獣医病理学

Research Projects

ネコのリンパ腫におけるEZH2の細胞増殖活性制御機構の解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025

町田雪乃

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