2018年11月
Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice
Journal of Stroke and Cerebrovascular Diseases
- 巻
- 27
- 号
- 11
- 開始ページ
- 3084
- 終了ページ
- 3094
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jstrokecerebrovasdis.2018.06.039
- 出版者・発行元
- ELSEVIER SCIENCE BV
© 2018 Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both potentials of thrombolytic and neuroprotective effects, but its detailed neuroprotective mechanisms in ischemic stroke are still unclear. Here, we assessed the neuroprotective effects of SMTP-7 for anti-inflammatory and antiapoptosis mechanisms after 60 minutes of transient middle cerebral artery occlusion (tMCAO) in mice. Methods: After 60 minutes of tMCAO, 0.9% NaCl, tissue-type plasminogen activator (tPA), SMTP-7 or tPA+SMTP-7 was intravenously administrated through subclavian vein just before the reperfusion, and these mice were examined at 24 hours after reperfusion. We histologically assessed the antineuroinflammatory effect of SMTP-7 on the expressive changes of inflammatory markers in ischemic mouse brains. Results: Compared with the vehicle and tPA groups, SMTP-7 treatment significantly improved clinical scores and decreased the infarct volume and the numbers of TNF-α, nuclear factor-κB (NF-κB), nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3), and cleaved caspase-3-positive cells in the brain of mice at 24 hours after tMCAO but not p62-positive cells. However, tPA+SMTP-7 treatment did not show such effects. Conclusions: The present study suggested that SMTP-7 provides a therapeutic benefit for ischemic stroke mice through anti-inflammatory and antiapoptotic effects but not antiautophagic effect.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.039
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30078758
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000450569700026&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050858252&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85050858252&origin=inward
- ID情報
-
- DOI : 10.1016/j.jstrokecerebrovasdis.2018.06.039
- ISSN : 1052-3057
- eISSN : 1532-8511
- PubMed ID : 30078758
- SCOPUS ID : 85050858252
- Web of Science ID : WOS:000450569700026