論文

査読有り 国際誌
2020年6月13日

Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress.

Brain research
  • Katsuhiro Aikawa
  • ,
  • Takayuki Yoshida
  • ,
  • Yu Ohmura
  • ,
  • Kerise Lyttle
  • ,
  • Mitsuhiro Yoshioka
  • ,
  • Yuji Morimoto

1746
開始ページ
146980
終了ページ
146980
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.brainres.2020.146980

Juvenile stress, like that caused by childhood maltreatment, is a significant risk factor for psychiatric disorders such as depression later in life. Recently, the antidepressant effect of ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, has been widely investigated. However, little is known regarding its efficacy against depressive-like alterations caused by juvenile stress, which is clinically relevant in human depression. In the present study, we evaluated the antidepressant-like effect of ketamine in adult rats that had been subjected to juvenile stress. Depressive-like behavior was assessed using the forced swim test (FST), and electrophysiological and morphological alterations in the layer V pyramidal cells of the prelimbic cortex were examined using whole-cell patch-clamp recordings and subsequent recording-cell specific fluorescence imaging. We demonstrated that ketamine (10 mg/kg) attenuated the increased immobility time caused by juvenile stress in the FST, restored the diminished excitatory postsynaptic currents, and caused atrophic changes in the apical dendritic spines. Ketamine's effects reversing impaired excitatory/inhibitory ratio of postsynaptic currents were also revealed. These results indicated that ketamine could be effective in reversing the depression-like alterations caused by juvenile stress.

リンク情報
DOI
https://doi.org/10.1016/j.brainres.2020.146980
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32544501

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