論文

査読有り 責任著者 本文へのリンクあり
2022年12月22日

Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

Nature Communications
  • Hiroyuki Kawai
  • Youcef Bouchekioua
  • Naoya Nishitani
  • Kazuhei Niitani
  • Shoma Izumi
  • Hinako Morishita
  • Chihiro Andoh
  • Yuma Nagai
  • Masashi Koda
  • Masako Hagiwara
  • Koji Toda
  • Hisashi Shirakawa
  • Kazuki Nagayasu
  • Yu Ohmura
  • Makoto Kondo
  • Katsuyuki Kaneda
  • Mitsuhiro Yoshioka
  • Shuji Kaneko
  • 全て表示

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1
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-022-35346-7
出版者・発行元
Springer Science and Business Media LLC

Abstract

Appropriate processing of reward and aversive information is essential for survival. Although a critical role of serotonergic neurons in the dorsal raphe nucleus (DRN) in reward processing has been shown, the lack of rewarding effects with selective serotonin reuptake inhibitors (SSRIs) implies the presence of a discrete serotonergic system playing an opposite role to the DRN in the processing of reward and aversive stimuli. Here, we demonstrated that serotonergic neurons in the median raphe nucleus (MRN) of mice process reward and aversive information in opposite directions to DRN serotonergic neurons. We further identified MRN serotonergic neurons, including those projecting to the interpeduncular nucleus (5-HTMRN→IPN), as a key mediator of reward and aversive stimuli. Moreover, 5-HT receptors, including 5-HT2A receptors in the interpeduncular nucleus, are involved in the aversive properties of MRN serotonergic neural activity. Our findings revealed an essential function of MRN serotonergic neurons, including 5-HTMRN→IPN, in the processing of reward and aversive stimuli.

リンク情報
DOI
https://doi.org/10.1038/s41467-022-35346-7 本文へのリンクあり
URL
https://www.nature.com/articles/s41467-022-35346-7.pdf
URL
https://www.nature.com/articles/s41467-022-35346-7
ID情報
  • DOI : 10.1038/s41467-022-35346-7
  • eISSN : 2041-1723

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