論文

査読有り
2022年2月1日

Track-structure modes in particle and heavy ion transport code system (PHITS): application to radiobiological research

International Journal of Radiation Biology
  • Yusuke Matsuya
  • ,
  • Takeshi Kai
  • ,
  • Tatsuhiko Sato
  • ,
  • Tatsuhiko Ogawa
  • ,
  • Yuho Hirata
  • ,
  • Yuji Yoshii
  • ,
  • Alessio Parisi
  • ,
  • Thiansin Liamsuwan

98
2
開始ページ
148
終了ページ
157
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/09553002.2022.2013572
出版者・発行元
Informa UK Limited

Purpose In radiation physics, Monte Carlo radiation transport simulations are powerful tools to evaluate the cellular responses after irradiation. When investigating such radiation-induced biological effects, it is essential to perform track structure simulations by explicitly considering each atomic interaction in liquid water at the sub-cellular and DNA scales. The Particle and Heavy-Ion Transport code System (PHITS) is a Monte Carlo code which enables to calculate track structure at DNA scale by employing the track-structure modes for electrons, protons and carbon ions. In this paper, we review the recent development status and future prospects of the track-structure modes in the PHITS code. Conclusions To date, the physical features of these modes have been verified using the available experimental data and Monte Carlo simulation results reported in literature. These track-structure modes can be used for calculating microdosimetric distributions to estimate cell survival and for estimating initial DNA damage yields. The use of PHITS track-structure mode is expected not only to clarify the underlying mechanisms of radiation effects but also to predict curative effects in radiation therapy. The results of PHITS simulations coupled with biophysical models will contribute to the radiobiological studies by precisely predicting radiation-induced biological effects based on the Monte Carlo approach.

リンク情報
DOI
https://doi.org/10.1080/09553002.2022.2013572
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000734214900001&DestApp=WOS_CPL
URL
https://www.tandfonline.com/doi/pdf/10.1080/09553002.2022.2013572
ID情報
  • DOI : 10.1080/09553002.2022.2013572
  • ISSN : 0955-3002
  • eISSN : 1362-3095
  • Web of Science ID : WOS:000734214900001

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