論文

国際誌
2021年1月11日

Down-regulation of miR-140-3p is a cause of the interlukin-13-induced up-regulation of RhoA protein in bronchial smooth muscle cells.

Small GTPases
  • Yoshihiko Chiba
  • ,
  • Yusuke Ando
  • ,
  • Yasuna Kato
  • ,
  • Motohiko Hanazaki
  • ,
  • Hiroyasu Sakai

開始ページ
1
終了ページ
6
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/21541248.2021.1872318

The current study aimed to determine the role of a microRNA (miRNA), miR-140-3p, in the control of RhoA expression in bronchial smooth muscle cells (BSMCs). In cultured human BSMCs, incubation with interleukin-13 (IL-13) caused an up-regulation of RhoA protein concurrently with a down-regulation of miR-140-3p. Transfection of the cells with a miR-140-3p inhibitor caused an increase in basal RhoA protein level. Although a mimic of miR-140-3p had little effect on the basal RhoA level, its treatment inhibited the IL-13-induced up-regulation of RhoA. These findings suggest that RhoA expression is negatively regulated by miR-140-3p, and that the negative regulation is inhibited by IL-13 to cause an up-regulation of RhoA protein in BSMCs.

リンク情報
DOI
https://doi.org/10.1080/21541248.2021.1872318
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33427568
ID情報
  • DOI : 10.1080/21541248.2021.1872318
  • PubMed ID : 33427568

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