論文

国際誌
2021年7月6日

Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock.

Cell reports
  • Shinya Aoyama
  • Hyeon-Ki Kim
  • Rina Hirooka
  • Mizuho Tanaka
  • Takeru Shimoda
  • Hanako Chijiki
  • Shuichi Kojima
  • Keisuke Sasaki
  • Kengo Takahashi
  • Saneyuki Makino
  • Miku Takizawa
  • Masaki Takahashi
  • Yu Tahara
  • Shigeki Shimba
  • Kazuyuki Shinohara
  • Shigenobu Shibata
  • 全て表示

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開始ページ
109336
終了ページ
109336
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.celrep.2021.109336

The meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the effects of better protein distribution on muscle volume are largely unknown. Here, using the two-meals-per-day feeding model, we find that protein intake at the early active phase promotes overloading-induced muscle hypertrophy, in a manner dependent on the local muscle clock. Mice fed branched-chain amino acid (BCAA)-supplemented diets at the early active phase demonstrate skeletal muscle hypertrophy. However, distribution-dependent effects are not observed in ClockΔ19 or muscle-specific Bmal1 knockout mice. Additionally, we examined the relationship between the distribution of proteins in meals and muscle functions, such as skeletal muscle index and grip strength in humans. Higher muscle functions were observed in subjects who ingested dietary proteins mainly at breakfast than at dinner. These data suggest that protein intake at breakfast may be better for the maintenance of skeletal muscle mass.

リンク情報
DOI
https://doi.org/10.1016/j.celrep.2021.109336
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34233179
ID情報
  • DOI : 10.1016/j.celrep.2021.109336
  • PubMed ID : 34233179

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