yutaka hata - My portal

Profile Information

Affiliation: -

J-GLOBAL ID: 201101092189292005
researchmap Member ID: B000002020

Research Interests

Research Areas

Research History

2004 - 2009

教授, 東京医科歯科大学医歯(薬)学総合研究科
2007

教授, 東京医科歯科大学医歯学総合研究科・大学院
2006

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
2000 - 2005

教授, 東京医科歯科大学医歯学総合研究科・大学院
2004

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
2001 - 2003

Tokyo Medical and Dental University
2000 - 2001

Faculty of Medicine, Tokyo Medical and Dental University

Papers

Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes.

Masamichi Ito, Hironori Hara, Norifumi Takeda, Atsuhiko T Naito, Seitaro Nomura, Masaki Kondo, Yutaka Hata, Masanobu Uchiyama, Hiroyuki Morita, Issei Komuro

Journal of molecular and cellular cardiology, 128 90-95, Mar, 2019 Peer-reviewed
Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability.

Yuxiong Lu, Junichi Maruyama, Keiko Kuwata, Hiroyuki Fukuda, Hiroaki Iwasa, Kyoko Arimoto-Matsuzaki, Haruhiko Sugimura, Yutaka Hata

Biochemistry and biophysics reports, 16 130-137, Dec, 2018 Peer-reviewed
Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.

Hironori Hara, Norifumi Takeda, Masaki Kondo, Mio Kubota, Tatsuo Saito, Junichi Maruyama, Takayuki Fujiwara, Sonoko Maemura, Masamichi Ito, Atsuhiko T Naito …

JACC. Basic to translational science, 3(5) 639-653, Oct, 2018 Peer-reviewed
Hippo Pathway in Cancer, towards the Realization of Hippo-Targeted Therapy.

Hata Y

Cancers, 10(10), Oct, 2018 Peer-reviewed
The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and Cell Cycle Progression via Retinoblastoma Protein.

Hossain S, Iwasa H, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y

Molecular and cellular biology, 38(17), Sep, 2018 Peer-reviewed
A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules.

Li Q, Yoshimura H, Komiya M, Tajiri K, Uesugi M, Hata Y, Ozawa T

The Analyst, 143(14) 3472-3480, Jul, 2018 Peer-reviewed
Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells.

Timalsina S, Arimoto-Matsuzaki K, Kitamura M, Xu X, Wenzhe Q, Ishigami-Yuasa M, Kagechika H, Hata Y

Journal of biochemistry, 164(5) 381-391, Jul, 2018 Peer-reviewed
UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53.

Iwasa H, Sarkar A, Shimizu T, Sawada T, Hossain S, Xu X, Maruyama J, Arimoto-Matsuzaki K, Withanage K, Nakagawa K …

Cancer science, 109(9) 2767-2780, Jun, 2018 Peer-reviewed
Tumor suppressor C-RASSF proteins

Hiroaki Iwasa, Shakhawoat Hossain, Yutaka Hata

Cellular and Molecular Life Sciences, 75(10) 1773-1787, May 1, 2018 Peer-reviewed
Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth

Junichi Maruyama, Kazutoshi Inami, Fumiyoshi Michishita, Xinliang Jiang, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Norio Miyamura, Jun Hirayama …

Molecular Cancer Research, 16(2) 197-211, Feb 1, 2018 Peer-reviewed
BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Xu X, Iwasa H, Hossain S, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y

Genes to cells : devoted to molecular & cellular mechanisms, 22(12) 993-1003, Dec, 2017 Peer-reviewed
Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy

Shintaro Mandai, Susumu Furukawa, Manami Kodaka, Yutaka Hata, Takayasu Mori, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Daiei Takahashi, Yuki Yoshizaki …

SCIENTIFIC REPORTS, 7 46369, Apr, 2017 Peer-reviewed
Application of split-GFP reassembly assay to study myogenesis and myofusion in vitro

Manami Kodaka, Xiaoyin Xu, Zeyu Yang, Junichi Maruyama, Yutaka Hata

Methods in Molecular Biology, 1668 127-134, 2017 Peer-reviewed
The Hippo Pathway as Drug Targets in Cancer Therapy and Regenerative Medicine

Shunta Nagashima, Yijun Bao, Yutaka Hata

CURRENT DRUG TARGETS, 18(4) 447-454, 2017 Peer-reviewed
Domain analysis of Ras-association domain family member 6 upon interaction with MDM2

Aradhan Sarkar, Hiroaki Iwasa, Shakhawoat Hossain, Xiaoyin Xu, Takeru Sawada, Takanobu Shimizu, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Yutaka Hata

FEBS LETTERS, 591(2) 260-272, Jan, 2017 Peer-reviewed
Involvement of Brain-Enriched guanylate Kinase-Associated protein (BEGAIN) in chronic pain after peripheral nerve injury

Tayo Katano, Masafumi Fukuda, Hidemasa Furue, Maya Yamazaki, Manabu Abe, Masahiko Watanabe, Kazuhiko Nishida, Ikuko Yao, Akihiro Yamada, Yutaka Hata …

eNeuro, 3(5), Sep 1, 2016 Peer-reviewed
Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif

Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata

CANCER SCIENCE, 107(6) 791-802, Jun, 2016 Peer-reviewed
RASSF6; the Putative Tumor Suppressor of the RASSF Family

Hiroaki Iwasa, Xinliang Jiang, Yutaka Hata

CANCERS, 7(4) 2415-2426, Dec, 2015 Peer-reviewed
A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells

Shodai Kawano, Junichi Maruyama, Shunta Nagashima, Kazutoshi Inami, Wenzhe Qiu, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina …

JOURNAL OF BIOCHEMISTRY, 158(5) 413-423, Nov, 2015 Peer-reviewed
Alternatively spliced isoforms of WT1 control podocyte-specific gene expression

Jonathan Lefebvre, Michael Clarkson, Filippo Massa, Stephen T. Bradford, Aurelie Charlet, Fabian Buske, Sandra Lacas-Gervais, Herbert Schulz, Charlotte Gimpel, Yutaka Hata …

KIDNEY INTERNATIONAL, 88(2) 321-331, Aug, 2015 Peer-reviewed

Misc.

シナプス裏打ち蛋白質のシナプス局在化機構 (特集樹状突起)

神作愛, 畑裕

生体の科学, 54(2) 104-110, Mar, 2003
細胞極性を支える分子基盤 (特集上皮組織ベクトル輸送の分子量盤と機能制御)

飯田純子, 畑裕

蛋白質核酸酵素, 48(2) 140-148, Feb, 2003
神経・骨格筋系 PSDの構造とシナプス伝達 (〔2002年〕6月第5土曜特集イオンチャネルの最前線) -- (臓器でのイオンチャネルの働きと疾患)

平林享, 畑裕

医学のあゆみ, 201(13) 1113-1117, Jun 29, 2002
シナプス可塑性とシナプス裏打ち蛋白質 (シナプス可塑性の分子的実体)

大野秀樹, 畑裕

医学のあゆみ, 199(8) 539-542, Nov 24, 2001
神経伝達物質受容体の裏打ち構造--精神疾患とのかかわり (特集精神疾患の分子医学--基礎と臨床) -- (基礎)

矢尾育子, 畑裕

現代医療, 33(11) 2678-2684, 2001
細胞膜ドメインの成り立ちとその機能 (特集シグナル伝達の場としての細胞膜ドメイン)

畑裕

細胞工学, 18(8) 1102-1107, Aug, 1999
神経シナプス結合を裏打ちするPDZタンパク質 (特集シグナル伝達の場としての細胞膜ドメイン)

出口真紀, 畑裕, 高井義美

細胞工学, 18(8) 1133-1140, Aug, 1999
Molecular machanism of assembly of neurotransmitter receptors and cell adhesion molecules at postsynaptic density

HATA Yutaka

70(12) 1414-1418, Dec 25, 1998
The molecular mechanism underlying the assembly of receptors and cell adhesion molecules at synaptic junctions

HATA Yutaka, NAKANISHI Hiroyuki, TAKAI Yoshimi

21 175-175, Dec 1, 1998
BEGAIN : a novel neuronal protein interacting with the guanylate kinase domain of PSD-95/SAP90

DEGUCHI Maki, HATA Yutaka, IDE Nobuyuki, HIRAO Kazuyo, IRIE Mina, YAO Ikuko, TAKAI Yoshimi

21 646-646, Dec 1, 1998
Novel neuronal PDZ domain-containing proteins implicated in the structures of the postsynaptic density

YAO Ikuko, HATA Yutaka, IDE Nobuyuki, HIRAO Kazuyo, DEGUCHI Maki, IRIE Mina, NISHIOKA Hideo, MIZOGUCHI Akira, TAKAI Yoshimi

21 646-646, Dec 1, 1998
Cloning and charactrization of mammalian homologues of Caenorhabditis elegans lin-7

IRIE Mina, HATA Yutaka, DEGUCHI Maki, IDE Nobuyuki, HIRAO Kazuyo, YAO Ikuko, NISHIOKA Hideo, MIZOGUCHI Akira, TAKAI Yoshimi

21 646-646, Dec 1, 1998
Identifications of novel components of the submembrane structures of synaptic junctions

HATA Y., NAKANISHI H., TAKAI Y.

Biophysics, 37(2) S8, Sep 5, 1997
PSD-95/SAP90関連遺伝子のクローニングとその性状解析

入江美奈, 畑裕, 竹内勝一, 平尾和世, 豊田淳, 高井義美

日本分子生物学会年会プログラム・講演要旨集, 19 529-529, Aug 1, 1996
PSD-95/SAP90に結合する新しい蛋白質のクローニングとその性状解析

竹内勝一, 畑裕, 入江美奈, 平尾和世, 豊田淳, 高井義美

日本分子生物学会年会プログラム・講演要旨集, 19 530-530, Aug 1, 1996
405 肺癌における喀血死の検討

角田尚久, 松岡緑郎, 中谷武, 竹沢信治, 畑裕, 高橋英気, 吉良枝郎, 清水英男

肺癌, 25(6), Oct 5, 1985
43)刺激伝導系の広汎な異常を認めた心筋炎の1例 : 日本循環器学会第106回関東甲信越地方会

畑裕, 定利勝, 関根今生, 岡部富士子, 伊藤敬, 山川和夫, 松本進作, 尾形悦郎, 森国みどり, 鶴井博理

Japanese circulation journal, 47, Dec 1, 1983

Professional Memberships

Research Projects

Roles of scaffolding proteins in the formation of transportsome

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

HATA Yutaka, NAKAGAWA Kentaro, IKEDA Misunobu
蛋白相互作用モジュールの組み換えによる分子進化の再構成の試み

科学研究費補助金(萌芽研究), 萌芽研究, 文部科学省, 2006 - 2008

畑裕
シナプス形成に関与する接着分子ニューロリギンとその裏打ち構造の研究

科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2005 - 2005

畑裕, 平林享, 飯田純子
Study on switching mechanisms of protein-protein interactions underlying the establishment of cell polarity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2004 - 2005

HATA Yutaka, HIRABAYASHI Susumu, IIDA Junko
細胞周期の制御異常

科学研究費補助金(特定領域研究(C), 特定領域研究), 特定領域研究(C), 特定領域研究, 文部科学省, 2000 - 2004

秋山徹, 畑裕
Molecular links between vector transport machinery and cell adhesion machinery

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2000 - 2004

HATA Yutaka, NAKANISHI Hiroyuki
Protein-protein interactions underlying the formation of microdomains on the cell surface

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2003

HATA Yutaka
肺胞上皮細胞の変移の分子機構の解明

科学研究費補助金(萌芽的研究, 萌芽研究), 萌芽的研究, 萌芽研究, 文部科学省, 2001 - 2002

畑裕, 飯塚利彦
Study on molecular structures of synapses and epithelial junctions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2000 - 2001

HATA Yutaka
神経シナプス足場蛋白質S-SCAMの分子集積機構の解析

科学研究費補助金(特定領域研究(C)), 特定領域研究(C), 文部科学省, 2000 - 2000

畑裕
神経回路の成熟過程における神経シナプス構成分子の集積の解析

科学研究費補助金(特定領域研究(A)), 特定領域研究(A), 文部科学省, 2000 - 2000

畑裕