2021年9月27日
Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome.
PLoS pathogens
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- 巻
- 17
- 号
- 9
- 開始ページ
- e1009277
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.ppat.1009277
- 出版者・発行元
- Cold Spring Harbor Laboratory
<jats:p>During replication, RNA viruses accumulate genome alterations, such as mutations and deletions. The interactions between individual variants can determine the fitness of the virus population and, thus, the outcome of infection. To investigate the effects of defective interfering genomes (DI) on wild-type (WT) poliovirus replication, we developed an ordinary differential equation model. We experimentally determined virus and DI replication during co-infection, and use these data to infer model parameters. Our model predicts, and our experimental measurements confirm, that DI replication and encapsidation are the most important determinants for the outcome of the competition. WT replication inversely correlates with DI replication. Our model predicts that genome replication and effective DI genome encapsidation are critical to effectively inhibit WT production, but an equilibrium can be established which enables WT to replicate, albeit to reduce levels.</jats:p>
- リンク情報
- ID情報
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- DOI : 10.1371/journal.ppat.1009277
- ORCIDのPut Code : 100617419
- PubMed ID : 34570820
- PubMed Central 記事ID : PMC8496841