Yuichi Yoshimura

Profile Information

Affiliation: Institute for Protein Research, Osaka University
: West-Japan Branch, Lifematics Inc.

Degree: Ph.D.(Mar, 2012, Osaka University)

Researcher number: 70632248
J-GLOBAL ID: 201801020079444846
researchmap Member ID: B000303197

Research Interests

Research Areas

Research History

Aug, 2019 - Present

Visiting academic staff, Institute for Protein Research, Osaka University
Jan, 2019 - Present

West-Japan Branch, Lifematics
Apr, 2019 - Aug, 2019

Research Scientist, Graduate School of Integrated Sciences for Life, Hiroshima University
Apr, 2017 - Dec, 2018

Assistant Professor, Graduate School of Science, Hiroshima University
Jan, 2017 - Mar, 2017

Research Scientist, Graduate School of Science, Hiroshima University
Aug, 2013 - Dec, 2016

Postdoctoral Researcher, Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University
Aug, 2013 - Aug, 2015

European Molecular Biology Organization (EMBO) Fellow
Apr, 2013 - Mar, 2014

Visiting Research Scientist, Institute for Protein Research, Osaka University
Apr, 2012 - Aug, 2013

Postdoctoral Researcher, Institute for Protein Research, Osaka University

Education

Apr, 2009 - Mar, 2012

Department of Macromolecular Science, Graduate School of Science, Osaka University
Apr, 2007 - Mar, 2009

Department of Macromolecular Science, Graduate School of Science, Osaka University
Apr, 2003 - Mar, 2007

Faculty of Pharmaceutical Sciences, Kyoto University

Committee Memberships

Aug, 2018 - May, 2022

Editorial Committee Member of PSSJ archive, Protein Science Society of Japan (PSSJ)
Sep, 2017 - Aug, 2018

第19回若手NMR研究会世話人, 若手NMR研究会

Awards

Aug, 2021

JEOL Resonance Poster Award, ISMAR-APNMR 2021
Jun, 2018

Young Scientist Award, Protein Science Society of Japan
Nov, 2017

Young Scientists Poster Award, The Nuclear Magnetic Resonance Society of Japan
May, 2014

Young Scientist Award, Asia Pacific Protein Association (APPA)
May, 2011

Best Student Oral Presentation Prize, Asia Pacific Protein Association (APPA)

Research Projects

蛋白質天然変性領域がもたらす相転移ダイナミクスの構造基盤解析

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2019 - Mar, 2023

吉村優一
天然変性領域を介した蛋白質の凝集化のNMR構造動態解析

広島大学研究助成金（若手研究者支援）, 広島大学, 2018
家族性変異によるストレス顆粒過剰形成の分子機序解明

上原記念生命科学財団, 2017 - 2017
アミロイド形成における前駆体構造および蛋白質分子間相互作用の溶液ＮＭＲ解析

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, Apr, 2013 - Aug, 2013

吉村優一

Papers

How epigallocatechin gallate binds and assembles oligomeric forms of human alpha-synuclein.

Camilla B Andersen, Yuichi Yoshimura, Janni Nielsen, Daniel E Otzen, Frans A A Mulder

The Journal of biological chemistry, 100788-100788, May 18, 2021
Carbonyl 13C-detect solution-state protein NMR experiments to circumvent amide-solvent exchange broadening: Application to β2-microglobulin.

Yuichi Yoshimura, Masatomo So, Yohei Miyanoiri

Biochimica et biophysica acta. Proteins and proteomics, 1869(3) 140593-140593, Dec 23, 2020
Sensitive and simplified: a combinatorial acquisition of five distinct 2D constant-time 13C-1H NMR protein correlation spectra.

Yuichi Yoshimura, Frans A A Mulder

Journal of biomolecular NMR, Aug 17, 2020 Peer-reviewed
How internal cavities destabilize a protein.

Xue M, Wakamoto T, Kejlberg C, Yoshimura Y, Nielsen TA, Risør MW, Sanggaard KW, Kitahara R, Mulder FAA

Proceedings of the National Academy of Sciences of the United States of America, Sep, 2019 Peer-reviewed
How and why internal cavities destabilize proteins

Mulder Frans A. A, Xue Mengjun, Yoshimura Yuichi, Kitahara Ryo

FASEB JOURNAL, 32(1), Apr, 2018 Peer-reviewed
On the Kinetic and Thermodynamic Properties of Aryl Radicals Using Electrochemical and Theoretical Approaches

Koefoed Line, Vase Karina H, Stenlid Joakim H, Brinck Tore, Yoshimura Yuichi, Lund Henning, Pedersen Steen U, Daasbjerg Kim

CHEMELECTROCHEM, 4(12) 3212-3221, Dec, 2017 Peer-reviewed
MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions

Yuichi Yoshimura, Mats A. Holmberg, Predrag Kukic, Camilla B. Andersen, Alejandro Mata-Cabana, S. Fabio Falsone, Michele Vendruscolo, Ellen A. A. Nollen, Frans A. A. Mulder

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(20) 8269-8278, May, 2017 Peer-reviewed
Active-Site pKa Determination for Photoactive Yellow Protein Rationalizes Slow Ground-State Recovery

Nur Alia Oktaviani, Trijntje J. Pool, Yuichi Yoshimura, Hironari Kamikubo, Ruud M. Scheek, Mikio Kataoka, Frans A. A. Mulder

BIOPHYSICAL JOURNAL, 112(10) 2109-2116, May, 2017 Peer-reviewed
Unambiguous Determination of Protein Arginine Ionization States in Solution by NMR Spectroscopy

Yuichi Yoshimura, Nur Alia Oktaviani, Kento Yonezawa, Hironari Kamikubo, Frans A. A. Mulder

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(1) 239-242, Jan, 2017 Peer-reviewed
Aberrant increase of NMR signal in hydrogen exchange experiments. Observation and explanation

Mengjun Xue, Ryo Kitahara, Yuichi Yoshimura, Frans A. A. Mulder

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(3) 1185-1188, Sep, 2016 Peer-reviewed
Near-complete H-1, C-13, N-15 resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T

Natalia V. Kulminskaya, Yuichi Yoshimura, Kasper Runager, Charlotte S. Sorensen, Morten Bjerring, Maria Andreasen, Daniel E. Otzen, Jan J. Enghild, Niels Chr. Nielsen, Frans A. A. Mulder

BIOMOLECULAR NMR ASSIGNMENTS, 10(1) 25-29, Apr, 2016 Peer-reviewed
Detecting O-2 binding sites in protein cavities

Ryo Kitahara, Yuichi Yoshimura, Mengjun Xue, Tomoshi Kameda, Frans A. A. Mulder

SCIENTIFIC REPORTS, 6 20534, Feb, 2016 Peer-reviewed
Structural basis for RNA-genome recognition during bacteriophage Q beta replication

Heidi Gytz, Durita Mohr, Paulina Seweryn, Yuichi Yoshimura, Zarina Kutlubaeva, Fleur Dolman, Bosene Chelchessa, Alexander B. Chetverin, Frans A. A. Mulder, Ditlev E. Brodersen …

NUCLEIC ACIDS RESEARCH, 43(22) 10893-10906, Dec, 2015 Peer-reviewed
Easy and unambiguous sequential assignments of intrinsically disordered proteins by correlating the backbone N-15 or C-13' chemical shifts of multiple contiguous residues in highly resolved 3D spectra

Yuichi Yoshimura, Natalia V. Kulminskaya, Frans A. A. Mulder

JOURNAL OF BIOMOLECULAR NMR, 61(2) 109-121, Feb, 2015 Peer-reviewed
How Epigallocatechin Gallate Can Inhibit alpha-Synuclein Oligomer Toxicity in Vitro

Nikolai Lorenzen, Soren B. Nielsen, Yuichi Yoshimura, Brian S. Vad, Camilla Bertel Andersen, Cristine Betzer, Jorn D. Kaspersen, Gunna Christiansen, Jan S. Pedersen, Poul Henning Jensen …

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(31) 21299-21310, Aug, 2014 Peer-reviewed
Solubility and Supersaturation-Dependent Protein Misfolding Revealed by Ultrasonication

Yuxi Lin, Young-Ho Lee, Yuichi Yoshimura, Hisashi Yagi, Yuji Goto

LANGMUIR, 30(7) 1845-1854, Feb, 2014 Peer-reviewed
Acceleration of the depolymerization of amyloid β fibrils by ultrasonication.

Yagi H, Hasegawa K, Yoshimura Y, Goto Y

Biochimica et biophysica acta, 1834(12) 2480-2485, Dec, 2013 Peer-reviewed
A common mechanism underlying amyloid fibrillation and protein crystallization revealed by the effects of ultrasonication.

Kitayama H, Yoshimura Y, So M, Sakurai K, Yagi H, Goto Y

Biochimica et biophysica acta, 1834(12) 2640-2646, Dec, 2013 Peer-reviewed
Acceleration of the depolymerization of amyloid 13 fibrils by ultrasonication

Hisashi Yagi, Kyohei Hasegawa, Yuichi Yoshimura, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834(12) 2480-2485, Dec, 2013 Peer-reviewed
A common mechanism underlying amyloid fibrillation and protein crystallization revealed by the effects of ultrasonication

Hiroki Kitayama, Yuichi Yoshimura, Masatomo So, Kazumasa Sakurai, Hisashi Yagi, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834(12) 2640-2646, Dec, 2013 Peer-reviewed

Industrial Property Rights

特開2013-246012 過飽和析出物検出装置および過飽和析出物検出方法

後藤祐児, 八木寿梓, 吉村優一, 宗正智, 北山寛貴, 井戸幸吉
特許第5360447号過飽和析出物検出装置および過飽和析出物検出方法

後藤祐児, 八木寿梓, 吉村優一, 宗正智, 北山寛貴, 井戸幸吉

Misc.

How to Lift Chemical Shift Degeneracy for Sequential Resonance Assignments of Intrinsically Disordered Proteins in 3D NMR Spectra

吉村優一

生物物理(Web), 56(1) 040‐043 (J‐STAGE)-43, Jan, 2016
ガス圧NMR法によるタンパク質内部キャビティーと気体分子の相互作用研究

北原亮, 吉村優一, XUE Mengjun, 亀田倫史, MULDER Frans A.A

高圧討論会講演要旨集, 56th 63, Oct 27, 2015
Ultrasonication-forced amyloid fibrillation of proteins

Masatomo So, Yuichi Yoshimura, Yuji Goto

Advances in Organic Crystal Chemistry: Comprehensive Reviews 2015, 15-29, Aug 6, 2015
超音波を用いた蛋白質凝集検出装置HANABIの開発

八木寿梓, 梅本彩香, 北山寛貴, 吉村優一, 宗正智, 後藤祐児

日本生化学会大会(Web), 86th 2T06P-10(2P-094) (WEB ONLY)-10, Sep, 2013
超音波照射による蛋白質過飽和溶液からの蛋白質結晶およびアミロイド線維の析出

吉村優一, 林雨曦, 北山寛貴, 八木寿梓, 李映昊, 内木宏延, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 13th 103, May 31, 2013
蛋白質凝集検出装置(HANABI)の開発

八木寿梓, 梅本彩香, 吉村優一, 北山寛樹, 宗正智, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 13th 32, May 31, 2013
超音波によるタンパク質のアミロイド線維形成反応の促進 (特集ソノケミストリーとマイクロバブルの新展開)

宗正智, 吉村優一, 八木寿梓

ケミカルエンジニヤリング, 58(4) 303-309, Apr, 2013
ソノケミストリーとマイクロバブルの新展開超音波によるタンパク質のアミロイド線維形成反応の促進

宗正智, 吉村優一, 八木寿梓, 後藤祐児

ケミカルエンジニヤリング, 58(4) 303-309, Apr 1, 2013
アミロイド線維形成時に現れる過渡的中間体のキャラクタリゼーション

柳浩太郎, 櫻井一正, 吉村優一, 小沼剛, LEE Young‐Ho, 菅瀬謙治, 池上貴久, 内木宏延, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 12th 12, May 31, 2012
アミロイド線維形成時に現れる過渡的中間体のキャラクタリゼーション

柳浩太郎, 櫻井一正, 吉村優一, 小沼剛, LEE Young‐Ho, 菅瀬謙治, 池上貴久, 内木宏延, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 12th 104, May 31, 2012
超音波を用いたニワトリ卵白リゾチーム結晶化のモニタリング

北山寛貴, 八木寿梓, 吉村優一, 宗正智, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 12th 101, May 31, 2012
A14 Ultrasonication-Dependent Acceleration of Amyloid Fibril Formation

So Masatomo, Yoshimura Yuichi, Yagi Hisashi, Sakurai Kazumasa, Goto Yuji, Ogi Hirotsugu, Naiki Hironobu

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry, 21 85-86, 2012
溶液NMRによるβ2ミクログロブリンアミロイド線維形成のモノマー‐線維核相互作用機構の解明

櫻井一正, 柳浩太郎, 吉村優一, 小沼剛, 菅瀬謙治, 池上貴久, 内木宏延, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 11th 104, May 27, 2011
超音波処理下で作製した微細アミロイド線維の構造および物性のキャラクタリゼーション

吉村優一, 櫻井一正, 八木寿梓, 宗正智, LEE Young‐Ho, 荻博次, 内木宏信, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 11th 101, May 27, 2011
β₂‐ミクログロブリンが形成するアミロイド線維の溶液NMRによる直接観察

吉村優一, 櫻井一正, 李映昊, 池上貴久, 茶谷絵理, 内木宏延, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 10th 90, May 15, 2010
1P063 1YA0930 Identification of transient intermediates of the formation of the β2-microglobulin amyloid fibril by heteronuclear NMR techniques.(Protein:Property,Early Research in Biophysics Award Candidate Presentations,Early Research in Biophysics Award

SAKURAI Kazumasa, YANAGI Kotaro, YOSHIMURA Yuichi, KONUMA Tsuyoshi, IKEGAMI Takahisa, NAIKI Hironobu, GOTO Yuji

Seibutsu Butsuri, 50(2) S30, 2010
β₂‐ミクログロブリンが形成するアミロイド線維の溶液NMRによる運動性の解析

吉村優一, 櫻井一正, 茶谷絵理, 亀田篤司, 池上貴久, 内木宏延, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 9th 74, Apr 24, 2009
β2ミクログロブリンのフラグメントが形成するアミロイド線維構造の構造解析

吉村優一, 茶谷絵理, 酒井美世, 櫻井一正, 亀田篤司, 山口圭一, 内木宏延, 後藤祐児

日本蛋白質科学会年会プログラム・要旨集, 8th 119, May 23, 2008
モデル膜貫通ヘリックスの膜への分配の熱力学に対する,脂質頭部の電荷,膜流動性,側方圧の影響

矢野義明, 小倉まい, 吉村優一, 松崎勝巳

日本薬学会年会要旨集, 127th(3) 50, Mar 5, 2007

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Research Projects

Papers

Industrial Property Rights

Misc.

Menu

Coauthors