Miyauchi Yuu

Profile Information

Affiliation: 講師, 衛生化学研究室, 崇城大学薬学部

Degree: 修士（創薬科学）(九州大学大学院薬学府)
博士（創薬科学）(九州大学大学院薬学府)

Researcher number: 50799947
J-GLOBAL ID: 201801000240951876
researchmap Member ID: B000346477

Research Interests

Research Areas

Research History

Apr, 2020 - Present

Senior Assistant Professor, Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University
Nov, 2016 - Mar, 2020

Faculty of Pharmaceutical Sciences, Kyushu University
May, 2015 - Nov, 2016

Visiting Fellow, Pharmacogenetics Group, National Institute of Environmental Health Sciences (NIEHS)
Apr, 2015 - Apr, 2015

Faculty of Pharmaceutical Sciences, Kyushu University

Education

Apr, 2012 - Mar, 2015

創薬科学専攻博士後期課程, 薬学府, 九州大学大学院
Apr, 2010 - Mar, 2012

創薬科学専攻修士課程, 薬学府, 九州大学大学院
Apr, 2006 - Mar, 2010

School of Pharmaceutical Sciences, Kyushu University

Committee Memberships

Apr, 2021 - Mar, 2023

トピックス小委員, 日本薬学会「ファルマシア」

Major Awards

Nov, 2022

JSSX Award for Young Scientists, The Japanese Society for the Study of Xenobiotics
Nov, 2021

学術奨励賞, 日本薬学会九州山口支部
Sep, 2021

部会賞・金原賞, 日本薬学会環境・衛生部会

Major Papers

Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products.

Yuu Miyauchi, Haruna Koba, Madoka Sawai, Hisao Kansui, Shinji Takechi

The Journal of toxicological sciences, 48(5) 263-272, May, 2023 Peer-reviewedLead authorCorresponding author
The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9.

Yuu Miyauchi, Ken Kurohara, Akane Kimura, Madoka Esaki, Keiko Fujimoto, Yuko Hirota, Shinji Takechi, Peter I Mackenzie, Yuji Ishii, Yoshitaka Tanaka

Drug metabolism and pharmacokinetics, 35(5) 466-474, Oct, 2020 Peer-reviewedLead authorCorresponding author
UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression.

Yuu Miyauchi, Yoshitaka Tanaka, Kiyoshi Nagata, Yasushi Yamazoe, Peter I Mackenzie, Hideyuki Yamada, Yuji Ishii

British journal of pharmacology, 177(5) 1077-1089, Mar, 2020 Peer-reviewedLead author
Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region.

Yuu Miyauchi, Kiyoshi Nagata, Yasushi Yamazoe, Peter I Mackenzie, Hideyuki Yamada, Yuji Ishii

Molecular pharmacology, 88(4) 800-12, Oct, 2015 Peer-reviewedLead author

Misc.

奨励賞を受賞して

宮内優

日本薬物動態学会ニュースレター, 37(6), Dec, 2022
[Protein-Protein Interactions as Underlying Regulatory Mechanisms of Drug-metabolizing Enzyme Function].

Yuu Miyauchi

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 142(11) 1169-1175, Nov, 2022 Peer-reviewedInvitedCorresponding author
万病のもと「糖化産物」：生命にとって不可欠な糖がもたらすリスク

宮内優

環境・衛生薬学トピックス, Jun 1, 2022
Aryl hydrocarbon receptor(AHR)欠損ラットにおける低尿酸血症の詳細機構の解明:核酸代謝に着目した検討

宮尾宏哉, 塩路優子, 宮内優, 武田知起, 武田知起, 田中嘉孝, 石井祐次

日本薬学会九州支部大会講演要旨集, 38th (CD-ROM), 2021
Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences.

Yuu Miyauchi, Shinji Takechi, Yuji Ishii

Biological & pharmaceutical bulletin, 44(11) 1635-1644, 2021 Peer-reviewedInvitedLead authorCorresponding author
甘いだけではない糖との関係：終末糖化産物 (AGEs) による不妊の惹起

宮内優

ファルマシア, 56(10), 2020
学会道しるべ： 12th International ISSX Meetingに参加して

宮内優

日本薬物動態学会ニュースレター, 34(5), 2019
NEW FACE-NEW POWER: 多くの人々との「縁」に支えられて始まった私の研究者生活

宮内優

日本薬物動態学会ニュースレター, 33(4), 2018
展望：19th North American ISSX/29th JSSX meeting における Pre-Doctoral Poster Awards を受賞して

宮内優

日本薬物動態学会ニュースレター, 30(1), 2015
Cytochrome P450-dependent change in UDP-glucuronosyltransferase function and its reverse regulation

Yuji Ishii, Yuu Miyauchi, Hideyuki Yamada

Fifty Years of Cytochrome P450 Research, 307-326, Jan 1, 2014
薬物応答に関する個体差の新たな機構：CYP3A4とUGTの相互作用によるCYP3A4機能変動

石井祐次, 宮内優, 山田英之

臨床薬理の進歩, 9-16, 2013

Presentations

Investigation of the function of UDP-glucuronosyltransferase focusing on its enzymatic features: C-terminal cytoplasmic peptide and oligomer formation

PRIS 2023 in 2023 ICCP450/JSSX International Joint Meeting (Educational Lecture), Sep 27, 2023 Invited
Functional interactions between different drug-metabolizing enzymes: a novel approach for variance in CYP3A4 activity

Miyauchi Yuu

Nov, 2022
タンパク質間相互作用による薬物代謝酵素の制御機構

宮内優

第38回日本薬学会九州支部大会（受賞講演）, Nov, 2021
UDP-グルクロン酸転移酵素研究の基盤：小胞体局在機構、機能発現、およびシトクロムP450機能調節

宮内優

フォーラム2021衛生薬学・環境トキシコロジー（受賞講演）, Sep, 2021

Teaching Experience

Apr, 2020 - Present

Laboratory Work in Environmental Hygienic Chemistry (Sojo University)
Apr, 2020 - Present

Basic Scientific English (Sojo University)
Apr, 2020 - Present

Environmental Hygienic Chemistry (Sojo University)
Apr, 2020 - Mar, 2022

Study for safe use of medicines II (Sojo University)

Professional Memberships

Apr, 2021 - Present

American Society for Pharmacology and Experimental Therapeutics
Mar, 2019 - Present

International Society for the Study of Xenobiotics
Feb, 2019 - Present

THE JAPANESE SOCIETY OF TOXICOLOGY
May, 2010 - Present

THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
Oct, 2009 - Present

THE PHARMACEUTICAL SOCIETY OF JAPAN

Major Research Projects

UDP-グルクロン酸転移酵素の細胞質ペプチドによる空間を超えた酵素活性の制御：膜脂質との相互作用

第43回研究助成金, 薬学研究奨励財団, Apr, 2023 - Mar, 2025
シトクロムP450による肝障害惹起の機構解明：終末糖化産物に対する感受性の上昇

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2024

宮内優

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Major Awards

Major Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

Major Research Projects

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