2007年5月18日
HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth
Biochemical and Biophysical Research Communications
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- 巻
- 356
- 号
- 4
- 開始ページ
- 851
- 終了ページ
- 856
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2007.03.060
MYO18B is a class XVIII myosin, cloned as a tumor suppressor gene candidate. To investigate the mechanisms of MYO18B-dependent tumor suppression, MYO18B-interacting proteins were searched for by a yeast two-hybrid screen. HOMER2, a Homer/Ves1 family protein, was identified as a binding partner of MYO18B. These proteins co-localized in the regions of membrane protrusion and stress fiber, which are known as ones with filamentous actin-rich structures. Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression. © 2007 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bbrc.2007.03.060
- ISSN : 0006-291X
- eISSN : 1090-2104
- PubMed ID : 17386922
- SCOPUS ID : 34047093358