チャンヨンジエ (Yongjie Zhang) - マイポータル - researchmap

基本情報

所属: 金沢大学

J-GLOBAL ID: 201801000504638446
researchmap会員ID: B000315197

研究キーワード

4

研究分野

1

ライフサイエンス / 医療薬学 /

学歴

1

2013年9月 - 2017年9月

VU University Amsterdam, Molecular and Computational Toxicology

論文

8

High-performance liquid chromatography-based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions.

Zhang Y, Wijaya L, Dekker SJ, Vermeulen NPE, Commandeur JNM

Journal of pharmaceutical and biomedical analysis 156 181-188 2018年7月査読有り
Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.

den Braver-Sewradj SP, den Braver MW, Toorneman RM, van Leeuwen S, Zhang Y, Dekker SJ, Vermeulen NPE, Commandeur JNM, Vos JC

Chemical research in toxicology 31(2) 116-126 2018年2月査読有り
In vitro and cellular systems for the characterization of bioactivating and inactivating drug metabolizing enzymes in adverse drug reactions: Insights into amodiaquine idiosyncratic toxicity

チャンヨンジエ

Vrije Universiteit Amsterdam 2018年査読有り
Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals.

den Braver-Sewradj SP, den Braver MW, van Dijk M, Zhang Y, Dekker SJ, Wijaya L, Vermeulen NPE, Richert L, Commandeur JNM, Vos JC

Current drug metabolism 19(4) 370-381 2018年査読有り
Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.

Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM, Vos JC

Frontiers in pharmacology 9 388 2018年査読有り
Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity

Yongjie Zhang, Shalenie P. den Braver-Sewradj, J. Chris Vos, Nico P. E. Vermeulen, Jan N. M. Commandeur

TOXICOLOGY LETTERS 275 83-91 2017年6月査読有り
Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation

Stefan J. Dekker, Yongjie Zhang, J. Chris Vos, Nico P. E. Vermeulen, Jan N. M. Commandeur

CHEMICAL RESEARCH IN TOXICOLOGY 29(12) 2136-2144 2016年12月査読有り
Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol

Michiel W. den Braver, Yongjie Zhang, Harini Venkataraman, Nico P. E. Vermeulen, Jan N. M. Commandeur

TOXICOLOGY LETTERS 255 52-62 2016年7月査読有り

講演・口頭発表等

1

Evaluation of the protective effects of glutathione S-transferase P1 against the cytotoxicity of amodiaquine quinoneimine in HepG2 cells

ZHANG, Yongjie

2017 FIGON Dutch Medicine Days 2017年10月3日招待有り

所属学協会

1

International Society for the Study of Xenobiotics

共同研究・競争的資金等の研究課題

1

Characterization of human glutathione S-transferase P1-1-catalyzed glutathionylation of proteins: as a clue to understand the inter-individual difference in drug-induced toxicity

JSPS Grants-in-Aid for Scientific Research 2019年4月 - 2021年3月

チャンヨンジエ