論文

査読有り 国際誌
2022年2月1日

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Nature
  • Rigel Suzuki
  • Daichi Yamasoba
  • Izumi Kimura
  • Lei Wang
  • Mai Kishimoto
  • Jumpei Ito
  • Yuhei Morioka
  • Naganori Nao
  • Hesham Nasser
  • Keiya Uriu
  • Yusuke Kosugi
  • Masumi Tsuda
  • Yasuko Orba
  • Michihito Sasaki
  • Ryo Shimizu
  • Ryoko Kawabata
  • Kumiko Yoshimatsu
  • Hiroyuki Asakura
  • Mami Nagashima
  • Kenji Sadamasu
  • Kazuhisa Yoshimura
  • Mai Suganami
  • Akiko Oide
  • Mika Chiba
  • Hayato Ito
  • Tomokazu Tamura
  • Kana Tsushima
  • Haruko Kubo
  • Zannatul Ferdous
  • Hiromi Mouri
  • Miki Iida
  • Keiko Kasahara
  • Koshiro Tabata
  • Mariko Ishizuka
  • Asako Shigeno
  • Kenzo Tokunaga
  • Seiya Ozono
  • Isao Yoshida
  • So Nakagawa
  • Jiaqi Wu
  • Miyoko Takahashi
  • Atsushi Kaneda
  • Motoaki Seki
  • Ryoji Fujiki
  • Bahityar Rahmutulla Nawai
  • Yutaka Suzuki
  • Yukie Kashima
  • Kazumi Abe
  • Kiyomi Imamura
  • Kotaro Shirakawa
  • Akifumi Takaori-Kondo
  • Yasuhiro Kazuma
  • Ryosuke Nomura
  • Yoshihito Horisawa
  • Kayoko Nagata
  • Yugo Kawai
  • Yohei Yanagida
  • Yusuke Tashiro
  • Otowa Takahashi
  • Kazuko Kitazato
  • Haruyo Hasebe
  • Chihiro Motozono
  • Mako Toyoda
  • Toong Seng Tan
  • Isaac Ngare
  • Takamasa Ueno
  • Akatsuki Saito
  • Erika P. Butlertanaka
  • Yuri L. Tanaka
  • Nanami Morizako
  • Hirofumi Sawa
  • Terumasa Ikeda
  • Takashi Irie
  • Keita Matsuno
  • Shinya Tanaka
  • Takasuke Fukuhara
  • Kei Sato
  • 全て表示

603
7902
開始ページ
700
終了ページ
705
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41586-022-04462-1
出版者・発行元
Springer Science and Business Media LLC

<title>Abstract</title>The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern1. In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture experiments showed Omicron to be less fusogenic than Delta and than an ancestral strain of SARS-CoV-2. Although the spike (S) protein of Delta is efficiently cleaved into two subunits, which facilitates cell–cell fusion2,3, the Omicron S protein was less efficiently cleaved compared to the S proteins of Delta and ancestral SARS-CoV-2. Furthermore, in a hamster model, Omicron showed decreased lung infectivity and was less pathogenic compared to Delta and ancestral SARS-CoV-2. Our multiscale investigations reveal the virological characteristics of Omicron, including rapid growth in the human population, lower fusogenicity and attenuated pathogenicity.

リンク情報
DOI
https://doi.org/10.1038/s41586-022-04462-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35104835
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942852
URL
https://www.nature.com/articles/s41586-022-04462-1.pdf
URL
https://www.nature.com/articles/s41586-022-04462-1
ID情報
  • DOI : 10.1038/s41586-022-04462-1
  • ISSN : 0028-0836
  • eISSN : 1476-4687
  • PubMed ID : 35104835
  • PubMed Central 記事ID : PMC8942852

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