Zeynep Bal

Profile Information

Affiliation: Assistant Professor, WPI Immunology Frontier Research Center, Osaka University

Degree: PhD(Mar, 2021, Osaka University)

Researcher number: 40924064
ORCID iD: https://orcid.org/0000-0003-1563-5036
J-GLOBAL ID: 202101006320832375
researchmap Member ID: R000030373

External link: https://www.researchgate.net/profile/Zeynep-Bal-4

Research Interests

Research Areas

Life sciences / Cell biology / Signal Transduction, Vascularisation, Bone, Cartilage
Life sciences / Biomaterials / nano materials, composite materials, polymers

Research History

Jul, 2021 - Present

(Specially Appointed Assistant Professor), Signal Transduction, Osaka University WPI Immunology Frontier Research Center
Apr, 2021 - Jun, 2021

(Specially Appointed Researcher), Signal Transduction, Osaka University Research Institute for Microbial Diseases
Jul, 2013 - Aug, 2013

(Intern), MANA, Smart Materials., National Institute for Materials Science

Awards

Sep, 2024

Best Biology Oral Presentation, Developing a trauma mouse model for osteonecrosis of the femoral head, European Orthopaedic Research Society

Zeynep Bal, Nobuyuki Takakura
Sep, 2024

Best New Investigator Oral Presentations Session, Developing a trauma mouse model for osteonecrosis of the femoral head, European Orthopaedic Research Society

Zeynep Bal, Nobuyuki Takakura
Sep, 2018

Best Orthoregeneration Study Award, A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration, ON Foundation, EORS (European Orthopaedic Research Society)

Zeynep Bal, Takashi Kaito, Hiroyuki Ishiguro, Petek Korkusuz, Eda Ciftci Dede, Feza Korkusuz

Papers

Hydrogel Use in Osteonecrosis of the Femoral Head

Zeynep Bal, Nobuyuki Takakura

Gels, 10(8) 544-544, Aug 22, 2024 Peer-reviewedInvitedLead authorCorresponding author
A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells

Eda Çiftci Dede, Merve Gizer, Feza Korkusuz, Zeynep Bal, Hiroyuki Ishiguro, Hideki Yoshikawa, Takashi Kaito, Petek Korkusuz

JOR SPINE, 6(3), Jun, 2023
骨におけるSmurf2のBMP/Smadシグナル伝達に対する新たな負の制御機構

串岡純一, 海渡貴司, 岡田倫太郎, 石黒博之, Bal Zeynep, 小玉城, 千々松良太, Pye Melanie, 成松雅博, Wrana Jeffrey L. …

日本整形外科学会雑誌, 97(3) S675-S675, Mar, 2023
Effects of rhBMP-2-loaded hydroxyapatite granules/beta-tricalcium phosphate hydrogel (HA/β-TCP/hydrogel) composite on a rat model of caudal intervertebral fusion

Shinichi Nakagawa, Rintaro Okada, Junichi Kushioka, Joe Kodama, Hiroyuki Tsukazaki, Zeynep Bal, Daisuke Tateiwa, Yuichiro Ukon, Hiromasa Hirai, Takahiro Makino …

Scientific Reports, 12(1), May 12, 2022
Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone

Yuichiro Ukon, Masahiro Nishida, Natsumi Yamamori, Kazuhiro Takeyama, Kazuhito Sakamoto, Shota Takenaka, Takahiro Makino, Takahito Fujimori, Yusuke Sakai, Yuya Kanie …

Frontiers in Bioengineering and Biotechnology, 10, Mar 17, 2022
Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation

Daisuke Tateiwa, Takashi Kaito, Kunihiko Hashimoto, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Hiroyuki Tsukazaki, Shinichi Nakagawa, Yuichiro Ukon …

Frontiers in Cell and Developmental Biology, 10, Mar 14, 2022
Effects of rhBMP-2 Loaded Hydroxyapatite Granules/beta-Tricalcium Phosphate Hydrogel (HA/β-TCP hydrogel) Composite on a Rat Model of Coccygeal Intervertebral Fusion.

Shinichi Nakagawa, Rintaro Okada, Junichi Kushioka, Joe Kodama, Hiroyuki Tsukazaki, Zeynep Bal, Daisuke Tateiwa, Yuichiro Ukon, Hiromasa Hirai, Takahiro Makino …

Nov 16, 2021
A novel BMP-2–loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite for bone regeneration

Daisuke Tateiwa, Shinichi Nakagawa, Hiroyuki Tsukazaki, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Yuichiro Ukon, Hiromasa Hirai, Takashi Kaito

Scientific Reports, 11(1), Aug 19, 2021
Antibacterial efficacy of quaternized chitosan coating on 3D printed titanium cage in rat intervertebral disc space

Joe Kodama, Hongfang Chen, Tangjun Zhou, Junichi Kushioka, Rintaro Okada, Hiroyuki Tsukazaki, Daisuke Tateiwa, Shinichi Nakagawa, Yuichiro Ukon, Zeynep Bal …

The Spine Journal, 21(7) 1217-1228, Jul, 2021
Low magnetic field promotes recombinant human BMP-2-induced bone formation and influences orientation of trabeculae and bone marrow-derived stromal cells

Rintaro Okada, Kai Yamato, Minoru Kawakami, Joe Kodama, Junichi Kushioka, Daisuke Tateiwa, Yuichiro Ukon, Bal Zeynep, Takuya Ishimoto, Takayoshi Nakano …

Bone Reports, 14 100757-100757, Jun, 2021
A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration

Zeynep Bal, Feza Korkusuz, Hiroyuki Ishiguro, Rintaro Okada, Junichi Kushioka, Ryota Chijimatsu, Joe Kodama, Daisuke Tateiwa, Yuichiro Ukon, Shinichi Nakagawa …

The Spine Journal, 21(5) 865-873, May, 2021
3D印刷技術およびキトサン加工による抗菌椎間ケージの開発

小玉城, 陳宏方, 周唐峻, ゼイネップ・バル, 塚崎裕之, 串岡純一, 立岩大輔, 右近裕一朗, 中川真一, 田海軍 …

Journal of Spine Research, 12(3) 347-347, Mar, 2021
骨芽細胞特異的Men1遺伝子ノックアウトマウスを用いた骨老化動物モデルの確立

右近裕一朗, 海渡貴司, 串岡純一, Bal Zeynep, 小玉城, 塚崎裕之, 立岩大輔, 中川真一, 萩澤宏樹, 平井宏昌 …

Journal of Spine Research, 12(3) 537-537, Mar, 2021
The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells

Junichi Kushioka, Takashi Kaito, Ryota Chijimatsu, Rintaro Okada, Hiroyuki Ishiguro, Zeynep Bal, Joe Kodama, Fumiko Yano, Taku Saito, Ung-il Chung …

Scientific Reports, 10(1), Dec, 2020
A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

Junichi Kushioka, Takashi Kaito, Rintaro Okada, Hiroyuki Ishiguro, Zeynep Bal, Joe Kodama, Ryota Chijimatsu, Melanie Pye, Masahiro Narimatsu, Jeffrey L. Wrana …

Bone Research, Nov 23, 2020
BMP and TGFβ use and release in bone regeneration

Zeynep BAL, Junichi KUSHIOKA, Joe KODAMA, Takashi KAITO, Hideki YOSHIKAWA, Petek KORKUSUZ, Feza KORKUSUZ

TURKISH JOURNAL OF MEDICAL SCIENCES, 50(7) 1707-1722, Nov 3, 2020 Peer-reviewedInvitedLead author
3D印刷技術およびキトサンコーティングによる抗菌椎間ケージの開発

小玉城, 田海軍, 陳宏方, 周唐峻, Bal Zeynep, 塚崎裕之, 立岩大輔, 右近裕一朗, 中川真一, 海渡貴司

日本整形外科学会雑誌, 94(8) S1881-S1881, Sep, 2020
レチノイン酸受容体γアンタゴニストとBMPを組み合わせた新規骨再生治療の可能性

立岩大輔, 海渡貴司, 小玉城, Bal Zeynep, 塚崎裕之, 中川真一, 右近裕一朗, 岩本容泰

日本整形外科学会雑誌, 94(8) S1916-S1916, Sep, 2020
Men1遺伝子ノックアウトマウスを用いた骨老化動物モデルの確立

右近裕一朗, 海渡貴司, Bal Zeynep, 小玉城, 塚崎裕之, 立岩大輔, 中川真一, 萩澤宏樹, 平井宏昌, 今村健志

日本整形外科学会雑誌, 94(8) S1960-S1960, Sep, 2020
Assessment of effects of rhBMP-2 on interbody fusion with a novel rat model

Rintaro Okada, Takashi Kaito, Hiroyuki Ishiguro, Junichi Kushioka, Satoru Otsuru, Sadaaki Kanayama, Zeynep Bal, Kazuma Kitaguchi, Kunihiko Hashimoto, Takahiro Makino …

The Spine Journal, 20(5) 821-829, May, 2020

Misc.

Oral Presentation : Nanohydroxyapatite, Polylactic Acid Polyethylene Glycol Copolymer and rhBMP-2 as a novel composite for bone regeneration

Zeynep Bal, Takashi Kaito, Hiroyuki Ishiguro, Rintaro Okada, Sadaaki Kanayama, Junichi Kushioka, Ryota Chijimatsu, Hideki Yoshikawa, Eda Ciftci-Dede, Merve Gizer …

European Orthopaedic Research Society, Sep, 2020 Lead author
Poster Presentation : rhBMP-2/PLA-PEG/ナノハイドロキシアパタイトによる作成した新規バイオマテリアルを用いた骨再生技術の確立

Bal Zeynep、海渡貴司、石黒博之、橋本国彦、岡田倫太郎、串岡純一、Kodoma Joe、牧野孝洋、武中章太、Korkusuz Feza、秀樹吉川

日本整形外科学会基礎学術集会, Oct, 2019 Lead author
Oral Presentation : A Novel Composite of Nanohydroxyapatite (nHAp), Synthetic Poymer (PLA-PEG) and Bone Morphogenetic Protein 2(rhBMP-2) for Bone Regeneration

Zeynep Bal, Kaito Takashi, Hiroyuki Ishiguro, Rintaro Okada, Junichi Kushioka, Petek Korkusuz, Eda Ciftci Dede, Hideki Yoshikawa, Feza Korkusuz

Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter, Greece, May, 2019 Lead author
Poster Presentation : A New Technology for Bone Regeneration with a Novel Composite of Nanohydroxyapatite (nHAp), Synthetic Polymer (PLA-PEG) and Bone Morphogenetic Protein-2 (rhBMP-2)

Bal Z, Kaito T, Ishiguro H, Makino T, Takenaka S, Kanayama S, Hashimoto K, Okada R, Kushioka J, Korkusuz P …

Orthopaedic Research Society, USA, Feb, 2019
Poster Presentation: The Development of rhBMP-2 Carrying Composites Containing Polylactic Acid-Polyethylene Glycol and Nano-Hydorxyapatite (PLA-PEG/nHAp) for Osteoporotic Spine Fusion

Korkusuz Petek, Kaito Takashi, Korkusuz Feza, Ishiguro Hiroyuki, Dede Çiftçi Eda, Bal Zeynep, Köse Seda, Gizer Merve

Turkish Society of Histology and Embryology, Sep, 2018
Oral Presentation : rhBMP-2/PLA-PEG/ナノハイドロキシアパタイトを用いた新規複合体バイオマテリアルによる骨再生技術の確立

Bal Zeynep, 海渡貴司、石黒博之、牧野孝洋、武中章太、金山完哲、橋本国彦、岡田倫太郎、串岡純一, Korkusuz Petek, Ciftci Dede Eda, Korkusuz Feza

第33回日本整形外科学会基礎学術集会, Sep, 2018 Lead author
Oral Presentation : A new composite biomaterial of osteoinductive nanohydroxyapatite (nHAp), synthetic polymer (PLA-PEG) and bone morphogenetic protein -2 (rhBMP-2) for bone regeneration

Zeynep Bal, Takashi Kaito, Hiroyuki Ishiguro, Petek Korkusuz, Eda Ciftci Dede, Feza Korkusuz

European Orthopaedic Research Society (EORS), Sep, 2018 Lead author
Oral Presentation : Does Bone Morphogenic Protein-2 Containing PLA-PEG Nanohydroxyapatite Composites Spine Fusion?

Korkusuz Feza, Kaito Takashi, Ishiguro Hiroyuki, Bal Zeynep, Korkusuz Petek, Köse Seda, Dede Ciftci Eda, Gizer Merve

70th Annual Meeting of the Association of Bone and Joint Surgeons, Portugal, May, 2018
Oral Presentation : A New Technology for Bone Regeneration with Bone Morphogenetic Protein-2 (rhBMP-2), Synthetic Polymer (PLA-PEG) and Osteoinductive Nanohydroxyapatite (nHAp) Composite

Zeynep Bal, Takashi Kaito, Hiroyuki Ishiguro, Takahiro Makino, Shota Takenaka, Sadaaki Kanayama, Kunihiko Hashimoto, Rintaro Okada, Junichi Kushioka, Petek Korkusuz …

Japanese Society for Spine Surgery and Related Research, Apr, 2018 Lead author
Oral Presentation : Bone Regeneration Stimulation with Osteoinductive Nanohydroxyapatite nd BMP

Korkusuz Feza, Kaito Takashi, Korkusuz Petek, Ishiguro Hiroyuki, Ciftci Dede Eda, Bal Zeynep

International Biomedical Science and Technology Symposium, Oct, 2017 Invited
Poster Presentation : A new technology for bone regeneration with bone morphogenetic protein-2 (rhBMP-2), synthetic polymer (PLA-PEG) and osteoinductive nano hydroxyapatite (nHAp) composite

Hiroyuki Ishiguro, Takashi Kaito, Zeynep Bal, Petek Korkusuz, Eda Çiftci Dede, Feza Korkusuz

Sep, 2017
Oral Presentation : A New Approach at Bone Regeneration: Composite that Contained Bone Morphogenic Protein-2 (rhBMP-2), Synthetic Polymer (PLA-PEG) and Osteoinductive Nano-Hydroxyapatite (nHAp)

Korkusuz Petek, Kaito Takashi, Korkusuz Feza, Ishiguro Hiroyuki Ciftci Dede Eda, Bal Zeynep, Köse Seda, Gizer Merve

TOTBID (Turkish Society of Orthopaedics and Traumatology) Congress, May, 2017
Review Article : Kemik grefti yerine geçen substratlar ve etki mekanizmaları

Feza Korkusuz, Eda Çiftci Dede, Zeynep Bal, Merve Gizer, Hiroyuki Ishiguro, Takashi Kaito, Necdet Sağlam, Petek Korkusuz

TOTBID Dergisi, 16(6), 2017

Presentations

The Use of Hydrogels in Femoral Head Necrosis Research

Zeynep Bal, Nobuyuki Takakura

INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS SCIENCE & ENGINEERING AND HIGH TECH DEVICE APPLICATIONS, Oct 25, 2024 Invited
Developing a trauma mouse model for osteonecrosis of the femoral head

Zeynep Bal, Nobuyuki Takakura

European Orthopaedic Research Society (EORS), Sep 18, 2024
Developing a small animal trauma model for osteonecrosis of the femoral head (ONFH) and Elucidation of the molecular mechanisms behind ONFH

Zeynep Bal

622nd Biken Monthly Seminar, Oct 24, 2023 Invited
Molecular Regulations and Cellular Interactions in Bone Regeneration

Zeynep Bal

FBS Colloquia No. 304, Jul 14, 2022 Invited

Professional Memberships

Sep, 2024 - Present

European Orthopaedic Research Society (EORS)
Nov, 2023 - Present

Sigma-Xi
Aug, 2017 - Present

Orthopedic Research Society (ORS)
Mar, 2019 - Mar, 2022

TERMIS Europe
Sep, 2018 - Sep, 2021

European Orthopaedic Research Society (EORS)

Research Projects

Elucidation of the Molecular Mechanisms Behind Avascular Necrosis

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2023 - Mar, 2025

ZEYNEP BAL

Other

Japanese Government Scholarship (MEXT)

Apr, 2017 - Mar, 2021

PhD Scholarship
Japanese Government Scholarship (MEXT)

Apr, 2016 - Mar, 2017

Research student

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