Apr, 2014 - Mar, 2017
The roles of RAC2-VAV1 signaling in oncogenesis and sarcomatoid differentiation of renal cell carcinoma
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 26462399
- Japan Grant Number (JGN)
- JP26462399
- Grant amount
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- (Total)
- 4,810,000 Japanese Yen
- (Direct funding)
- 3,700,000 Japanese Yen
- (Indirect funding)
- 1,110,000 Japanese Yen
We evaluated the expression of VAV1 in samples of patient with clear cell renal cell carcinoma (ccRCC) by Quantitative RT-PCR. The mRNA expressions of VAV1 were elevated in ccRCC. However, cell proliferation and invasion were not suppressed by VAV1 knockdown in renal cancer cell lines. Therefore, we next focused on PLD2 as the guanine nucleotide exchange factor of RAC2. We evaluated the expression of PLD2 in samples of patient with ccRCC by immunohistochemical staining. The high expression of PLD2 was significantly associated with a poorer prognosis in patients with ccRCC. Moreover, cell proliferation and invasion were suppressed by PLD2 knockdown in renal cancer cell lines. These results suggest that PLD2 may become a new target of therapy for ccRCC.
- Link information
- ID information
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- Grant number : 26462399
- Japan Grant Number (JGN) : JP26462399