Hiroshi Watanabe

Profile Information

Affiliation: Assistant Professor (PI), Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University

Degree: Ph.D.

J-GLOBAL ID: 201801012233195800
researchmap Member ID: B000322457

External link: https://groups.oist.jp/enbu

Research Interests

Research Areas

Research History

Feb, 2023 - Present

Associate Professor, Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University
Feb, 2016 - Feb, 2023

Assistant Professor (PI), Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University
Dec, 2014 - Dec, 2015

Research Associate, Department of Molecular Evolution & Genomics, University of Heidelberg, Centre for Organismal Studies (COS)
Aug, 2011 - Nov, 2014

PostDoc (FOR1036/2 DFG), Department of Molecular Evolution & Genomics, University of Heidelberg, Centre for Organismal Studies (COS)
Jul, 2009 - Jul, 2011

PostDoc (SFB488 German Research Community), Department of Molecular Evolution & Genomics, Heidelberg Institute of Zoology
Jul, 2008 - Jun, 2009

Research fellow (Bioquant), Department of Molecular Evolution & Genomics, Heidelberg Institute of Zoology
Apr, 2006 - Jun, 2008

PostDoc (Alexander von Humboldt Foundation), Department of Molecular Evolution & Genomics, Heidelberg Institute of Zoology
Apr, 2005 - Mar, 2006

PostDoc, Department of Molecular Evolution & Genomics, Heidelberg Institute of Zoology
Apr, 2002 - Mar, 2005

Research Investigator, Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science

Education

Apr, 1999 - Mar, 2002

Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Apr, 1997 - Mar, 1999

Department of Bioscience, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Apr, 1993 - Mar, 1997

Department of Biological Science and Technology, The School of high-Technology for Human Welfare, Tokai University

Papers

Neuronal and non-neuronal functions of the synaptic cell adhesion molecule, neurexin, in Nematostella vectensis.

Christine Guzman, Kurato Mohri, Yuko Tsuchiya, Kentaro Tomii, Hiroshi Watanabe

bioRxiv, Apr, 2024 Last authorCorresponding author
Neuromuscular organization of the benthic ctenophore, Vallicula multiformis.

Kurato Mohri, Hiroshi Watanabe

Zoological letters, 10(1) 3-3, Jan 30, 2024 Peer-reviewedCorresponding author
Analysis of cnidarian Gcm suggests a neuronal origin of glial EAAT1 function.

Larisa Sheloukhova, Hiroshi Watanabe

Scientific reports, 13(1) 14790-14790, Sep 8, 2023 Peer-reviewedCorresponding author
Cnidarian pharyngeal nervous system illustrates prebilaterian neurosecretory regulation of feeding

Ryo Nakamura, Ryotaro Nakamura, Hiroshi Watanabe

bioRxiv, Apr, 2023 Last authorCorresponding author
siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos.

Tokiha Masuda-Ozawa, Sosuke Fujita, Ryotaro Nakamura, Hiroshi Watanabe, Erina Kuranaga, Yu-Ichiro Nakajima

Scientific Reports, 12(1) 16049-16049, Sep 30, 2022 Peer-reviewed
Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons

Eisuke Hayakawa, Christine Guzman, Osamu Horiguchi, Chihiro Kawano, Akira Shiraishi, Kurato Mohri, Mei-Fang Lin, Ryotaro Nakamura, Ryo Nakamura, Erina Kawai …

Nature Ecology & Evolution, Aug, 2022 Peer-reviewedCorresponding author
Emergence of a Thrombospondin Superfamily at the Origin of Metazoans.

Shoemark DK, Ziegler B, Watanabe H, Strompen J, Tucker RP, Özbek S, Adams JC

Molecular Biology and Evolution, Mar, 2019 Peer-reviewed
A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis.

Hayakawa E, Watanabe H, Menschaert G, Holstein TW, Baggerman G, Schoofs L.

PLoS One, 14(9), 2019 Peer-reviewed
Sequential actions of beta-catenin and Bmp pattern the oral nerve net in Nematostella vectensis

Hiroshi Watanabe, Anne Kuhn, Manami Fushiki, Kiyokazu Agata, Suat Oezbek, Toshitaka Fujisawa, Thomas W. Holstein

Nature Communications, 5 5536, Dec, 2014 Peer-reviewedLead authorCorresponding author
Nodal signalling determines biradial asymmetry in Hydra

Hiroshi Watanabe, Heiko A. Schmidt, Anne Kuhn, Stefanie K. Hoeger, Yigit Kocagoez, Nico Laumann-Lipp, Suat Oezbek, Thomas W. Holstein

Nature, 515(7525) 112-+, Nov, 2014 Peer-reviewedLead authorCorresponding author
Phospholipase D2 activation by p38 MAP kinase is involved in neurite outgrowth

Hiroshi Watanabe, Tsunaki Hongu, Masakazu Yamazaki, Yasunori Kanaho

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 413(2) 288-293, Sep, 2011 Peer-reviewed
SIGNALING PATHWAYS AND AXIS FORMATION IN THE LOWER METAZOA

Thomas W. Holstein, Hiroshi Watanabe, Suat Oezbek

GROWTH FACTORS IN DEVELOPMENT, 97 137-177, 2011 Peer-reviewed
The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons

Atsushi Suzuki, Chihiro Arikawa, Yuji Kuwahara, Kouichi Itoh, Masatomo Watanabe, Hiroshi Watanabe, Teruhiko Suzuki, Yuji Funakoshi, Hiroshi Hasegawa, Yasunori Kanaho

FEBS LETTERS, 584(13) 2801-2806, Jul, 2010 Peer-reviewed
The dynamic genome of Hydra

Jarrod A. Chapman, Ewen F. Kirkness, Oleg Simakov, Steven E. Hampson, Therese Mitros, Thomas Weinmaier, Thomas Rattei, Prakash G. Balasubramanian, Jon Borman, Dana Busam …

NATURE, 464(7288) 592-596, Mar, 2010 Peer-reviewed
Immortality and the base of multicellular life: Lessons from cnidarian stem cells

Hiroshi Watanabe, Van Thanh Hoang, Robert Maettner, Thomas W. Holstein

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 20(9) 1114-1125, Dec, 2009 Peer-reviewed
Multiple Wnts are involved in Hydra organizer formation and regeneration

Tobias Lengfeld, Hiroshi Watanabe, Oleg Simakov, Dirk Lindgens, Lydia Gee, Lee Law, Heiko A. Schmidt, Suat Oezbek, Hans Bode, Thomas W. Holstein

DEVELOPMENTAL BIOLOGY, 330(1) 186-199, Jun, 2009 Peer-reviewed
Cnidarians and the evolutionary origin of the nervous system

Hiroshi Watanabe, Toshitaka Fujisawa, Thomas W. Holstein

DEVELOPMENT GROWTH & DIFFERENTIATION, 51(3) 167-183, Apr, 2009 Peer-reviewed
Wnt/beta-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra

Isabelle Philipp, Roland Aufschnaiter, Suat Oezbek, Stefanie Pontasch, Marcell Jenewein, Hiroshi Watanabe, Fabian Rentzsch, Thomas W. Holstein, Bert Hobmayer

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(11) 4290-4295, Mar, 2009 Peer-reviewed
Control of cell polarity and motility by the PtdIns(3,4,5)P-3 phosphatase SHIP1

Miki Nishio, Ken-ichi Watanabe, Junko Sasaki, Choji Taya, Shunsuke Takasuga, Ryota Iizuka, Tamas Balla, Masakazu Yamazaki, Hiroshi Watanabe, Reietsu Itoh …

NATURE CELL BIOLOGY, 9(1) 36-U40, Jan, 2007 Peer-reviewed
The Wnt code: cnidarians signal the way

C. Guder, I. Philipp, T. Lengfeld, H. Watanabe, B. Hobmayer, T. W. Holstein

ONCOGENE, 25(57) 7450-7460, Dec, 2006 Peer-reviewed

Misc.

ネマトステラの領域化された神経系の発生とその制御

渡邉寛, 伏木真波, 伏木真波, 阿形清和, OEZBEK Suat, 藤澤敏孝, 藤澤敏孝, HOLSTEIN Thomas

日本動物学会大会予稿集, 85th, 2014
Accumulation of phosphatidylethanol produced by phosphotipase D is responsible for ethanol-induced apoptotic cell death

Arikawa, Chihiro, Hiroshi, Watanabe, Takeaki, Yokozeki, Yasunori, Kanaho

CELL STRUCTURE AND FUNCTION, 30 80-80, Jun, 2005
樹状突起スパイン形態制御へのホスファチジルイノシトール4-リン酸5-キナーゼの関与

宮崎秀幸, 山崎正和, 渡辺寛, 佐々木雄彦, 前濱朝彦, 金保安則

生化学, 74(8) 813-813, Aug, 2002
Cellular sonic signals regulating the growth of neighboring cells

M Matsuhashi, AN Pankrushina, K Endoh, H Watanabe, S Takeuchi, H Ohshima, H Miyoi, K Endo, M Tobi, K Murayama …

FASEB JOURNAL, 11(9) A983-A983, Jul, 1997

Books and Other Publications

遺伝子から解き明かす脳の不思議な世界

渡邉寛 (Role: Contributor, 第２章脳の起源︱中枢神経系の誕生)

一色出版, Jan, 2019
Back ThrouBrain Evolution by Design ?From Neural Origin to Cognitive Architechture- (Eds.: S. Shigeno, Y. Murakami and T. Nomura)gh Time: How Cnidarians and Basal Metazoans Shed Light on Ancient Nervous Systems.

Hiroshi Watanabe (Role: Contributor, Chaptor 3Chaptor 3: Back Through Time: How Cnidarians and Basal Metazoans Shed Light on Ancient Nervous Systems.)

Springer, Feb, 2017 (ISBN: 9784431564690)
Supercarbon -Synthesis, Properties and Applications-

Matsuhashi M, Takeuchi S, Pankrushina AN, Endoh K, Watanabe H, Endo S, Hiraoka N, Tobi M, Ohshima H, Miyoi H, Murayama K, Yamamura H, Kanoke T, Otani S (Role: Joint author, -Lactams and other innovative new approaches for controlling bacterial populations)

Springer, 1997

Presentations

Evolutionary Origin of the Central Nervous System: Insights from the development and function of cnidarian Pharyngeal Nervous System.

Hiroshi Watanabe

The 3rd AsiaEvo Conference, Dec 18, 2023 Invited
中枢神経系の進化的起源:刺胞動物の咽頭神経系の解析から見えてきたこと

渡邉寛

日本動物学会, Sep 9, 2023
Evolutionary origin of neurons: insights from peptide-expressing neurons of ctenophores.

Hiroshi Watanabe

The 93rd Annual Meeting of the Zoological Society of Japan, Sep 8, 2022
Common Features of Metazoan Peptidergic Neurons Support Their Single Origin

Hiroshi Watanabe

Jun 27, 2022
Molecular characteristics and developmental mechanism of Nematostella neuronal assemblies.

Watanabe, H

International Workshop "At the roots of bilaterian complexity: insights from early emerging metazoans", Sep 17, 2019
左右相称動物の中枢神経系と刺胞動物の集積神経系はホモロガスか？

Hiroshi Watanabe

The 20th Annual Meeting of tThe Society of Evolutionary Studies, Japan, Aug 23, 2018
Semi-Centralized Nervous System of the Sea Anemone Nematostella vectensis

Hiroshi Watanabe

International Workshop "The diversification of early emerging metazoans: a window into animal evolution?", Sep 13, 2017
刺胞動物の神経発生機構の解析:中枢神経系の初期進化過程の理解に向けて

渡邉寛, ホルスタイントーマス

日本進化学会大会プログラム・講演要旨集(Web), Aug 25, 2016
Beta-catenin and Bmp Signaling Induce the Semi-Centralized Nervous System in the Sea Anemone Nematostella vectensis

Hiroshi Watanabe

JSDB Special Symposium, Tokyo, Jun 2, 2016
Subsequent Actions of beta-Catenin and Bmp Pattern the Oral Nerve Net in Nematostella vectensis.

Hiroshi Watanabe

FOR 1036/2 Seminar, Heidelberg, Jun, 2015
β-Catenin and Bmp signalling induce the semi-centralized nervous system in the sea anemone Nematostella vectensis

Hiroshi Watanabe

Wnt Symposium 2015, May 27, 2015
Molecular and Cellular Reconstruction of CNS Evolution

Hiroshi Watanabe

Systematic Approaches in Organismal Biology, Mar 24, 2015
ネマトステラの領域化された神経系の発生とその制御

渡邉寛, 伏木真波, 阿形清和, OEZBEK Suat, 藤澤敏孝, HOLSTEIN Thomas

日本動物学会大会予稿集, Aug 7, 2014
Nodal Signalling Determines Biradial Asymmetry in the Cnidarian Hydra

Hiroshi Watanabe

Systematic Approaches in Organismal Biology, Jul 14, 2014
Subsequent Actions of beta-Catenin and Bmp Pattern the Oral Nerve Net in Nematostella vectensis.

Hiroshi Watanabe

FOR Seminar, Schöntal, Jun 14, 2014
Deciphering basic signaling architectures patterning animal body axes.

Hiroshi Watanabe

OIST seminar, Dec 10, 2013
Cnidaria as an attractive model to understand the developmental features in the last common eumetazoan ancestor.

Hiroshi Watanabe

The 36th Annual Meeting of the Molecular Biology Society of Japan. Kobe, Dec 4, 2013
Deciphering basic signaling architectures patterning animal body axes

Hiroshi Watanabe

RIKEN CDB Seminar, Dec 2, 2013
Nodal Signalling Determines Biradial Asymmetry in the Cnidarian Hydra

Hiroshi Watanabe

NIBB Seminar, Nov 27, 2013
Asymmetric Neural Patterning of the Sea Anemone Nematostella vectensis

Hiroshi Watanabe, Thomas Holstein

International Workshop "Unravelling the Developmental Regulatory Network in Early Animals", Sep 24, 2013

Teaching Experience

Jan, 2022 - Apr, 2022

Introductory Evolutionary Developmental Biology (OIST)
Jan, 2021 - Apr, 2021

Introductory Evolutionary Developmental Biology (OIST)
Jan, 2019 - Apr, 2019

Introductory Evolutionary Developmental Biology (OIST)
May, 2018 - Aug, 2018

Introductory Evolutionary Developmental Biology (OIST)
May, 2017 - Aug, 2017

Introductory Evodlutionary Developmental Biology (沖縄科学技術大学院大学)
Tutorial Lecture (Early Vertebrate Development, Stem Cell, Organogenesis) (ハイデルベルク大学)
生物学特別講義I (九州大学)
統合生命科学特別講義I (九州大学)

Professional Memberships

Research Projects

刺胞動物の咽頭神経系の発生・生理・機能学的解析で迫る集積神経系の進化的起源

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2026

渡邉寛
ペプチド作動性神経系に共通する分子シグネチャーに基づく祖先的神経細胞の再構築

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

渡邉寛, 早川英介, 稲葉一男
横断的クロスリンクプロテオミクスによるシナプスタンパク複合体の進化的起源の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

早川英介, 渡邉寛
胎児性アルコール症候群におけるホスホリパーゼD2の関与の解析

萌芽的研究補助金, 東京都臨床医学総合研究所, Apr, 2003 - Mar, 2004

渡邉寛
神経回路網形成におけるホスホリパーゼD2の機能解析

科学研究費補助金基盤研究（Ｂ）（分担者）, 日本学術振興会, Apr, 2002 - Mar, 2004

渡邉寛

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

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