Rena Onoguchi-Mizutani - My portal

Profile Information

Affiliation: Isotope Science Center, The University of Tokyo

Researcher number: 30780697
J-GLOBAL ID: 201901014316151210
researchmap Member ID: B000373069

Research Areas

Life sciences / Molecular biology /

Research History

2016 - Present

Radioisotope Center, The University of Tokyo

Education

Apr, 2013 - Mar, 2016

薬科学専攻博士課程, 薬学系研究科, 東京大学大学院
Apr, 2011 - Mar, 2013

薬科学専攻修士課程, 薬学系研究科, 東京大学大学院
Apr, 2007 - Mar, 2011

Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science

Papers

Long noncoding RNA and phase separation in cellular stress response.

Rena Onoguchi-Mizutani, Nobuyoshi Akimitsu

Journal of biochemistry, 171(3) 269-276, Mar 3, 2022 Peer-reviewedLead author
hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression.

Tanzina Tanu, Kenzui Taniue, Katsutoshi Imamura, Rena Onoguchi-Mizutani, Han Han, Torben Heick Jensen, Nobuyoshi Akimitsu

RNA biology, 18(sup1) 537-547, Oct 15, 2021 Peer-reviewed
A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.

Keita Yamamoto, Susumu Goyama, Shuhei Asada, Takeshi Fujino, Taishi Yonezawa, Naru Sato, Reina Takeda, Akiho Tsuchiya, Tomofusa Fukuyama, Yosuke Tanaka …

Cell reports, 36(8) 109576-109576, Aug 24, 2021 Peer-reviewed
Identification of a heat-inducible novel nuclear body containing the long noncoding RNA MALAT1.

Rena Onoguchi-Mizutani, Yoshitaka Kirikae, Yoko Ogura, Tony Gutschner, Sven Diederichs, Nobuyoshi Akimitsu

Journal of cell science, 134(10), May 15, 2021 Peer-reviewedLead author
Identification of novel heat shock-induced long non-coding RNA in human cells.

Rena Onoguchi-Mizutani, Yoshihiro Kishi, Yoko Ogura, Yuuki Nishimura, Naoto Imamachi, Yutaka Suzuki, Satoru Miyazaki, Nobuyoshi Akimitsu

Journal of biochemistry, 169(4) 497-505, Apr 29, 2021 Peer-reviewedLead author
Long noncoding RNA U90926 is crucial for herpes simplex virus type 1 proliferation in murine retinal photoreceptor cells

Shintaro Shirahama, Rena Onoguchi-Mizutani, Kentaro Kawata, Kenzui Taniue, Atsuko Miki, Akihisa Kato, Yasushi Kawaguchi, Rie Tanaka, Toshikatsu Kaburaki, Hidetoshi Kawashima …

Scientific Reports, 10(1), Dec, 2020 Peer-reviewed
Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.

Katsutoshi Imamura, Akiko Takaya, Yo-Ichi Ishida, Yayoi Fukuoka, Toshiki Taya, Ryo Nakaki, Miho Kakeda, Naoto Imamachi, Aiko Sato, Toshimichi Yamada …

The EMBO journal, 37(13), Jul 2, 2018 Peer-reviewed
The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency.

Daisuke Kami, Tomoya Kitani, Akihiro Nakamura, Naoki Wakui, Rena Mizutani, Masahito Ohue, Fuyuki Kametani, Nobuyoshi Akimitsu, Satoshi Gojo

PloS one, 13(10) e0203708, 2018 Peer-reviewed
5'-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives.

Toshimichi Yamada, Naoto Imamachi, Rena Onoguchi-Mizutani, Katsutoshi Imamura, Yutaka Suzuki, Nobuyoshi Akimitsu

Methods in molecular biology (Clifton, N.J.), 1720 1-13, 2018 Peer-reviewed
Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells.

Keiko Tano, Rena Onoguchi-Mizutani, Fouzia Yeasmin, Fumiaki Uchiumi, Yutaka Suzuki, Tetsushi Yada, Nobuyoshi Akimitsu

Frontiers in genetics, 8 208-208, 2017 Peer-reviewed
Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA

R. Onoguchi-Mizutani, N. Imamachi, Y. Suzuki, H. Yoshida, N. Tochigi, T. Oonishi, Y. Suzuki, N. Akimitsu

ONCOGENE, 35(27) 3495-3502, Jul, 2016 Peer-reviewedLead author
Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance

Sho Maekawa, Naoto Imamachi, Takuma Irie, Hidenori Tani, Kyoko Matsumoto, Rena Mizutani, Katsutoshi Imamura, Miho Kakeda, Tetsushi Yada, Sumio Sugano …

BMC GENOMICS, 16 154, Mar, 2015 Peer-reviewed
Genome-wide analysis of long noncoding RNA turnover.

Hidenori Tani, Naoto Imamachi, Rena Mizutani, Katsutoshi Imamura, Yeondae Kwon, Satoru Miyazaki, Sho Maekawa, Yutaka Suzuki, Nobuyoshi Akimitsu

Methods in molecular biology (Clifton, N.J.), 1262 305-20, 2015 Peer-reviewed
BRIC-seq: A genome-wide approach for determining RNA stability in mammalian cells

Naoto Imamachi, Hidenori Tani, Rena Mizutani, Katsutoshi Imamura, Takuma Irie, Yutaka Suzuki, Nobuyoshi Akimitsu

METHODS, 67(1) 55-63, May, 2014 Peer-reviewed
Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability

Hidenori Tani, Naoto Imamachi, Kazi Abdus Salam, Rena Mizutani, Kenichi Ijiri, Takuma Irie, Tetsushi Yada, Yutaka Suzuki, Nobuyoshi Akimitsu

RNA BIOLOGY, 9(11) 1370-1379, Nov, 2012 Peer-reviewed
Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals

Hidenori Tani, Rena Mizutani, Kazi Abdus Salam, Keiko Tano, Kenichi Ijiri, Ai Wakamatsu, Takao Isogai, Yutaka Suzuki, Nobuyoshi Akimitsu

GENOME RESEARCH, 22(5) 947-956, May, 2012 Peer-reviewed
Identification and Characterization of Novel Genotoxic Stress-Inducible Nuclear Long Noncoding RNAs in Mammalian Cells

Rena Mizutani, Ai Wakamatsu, Noriyuki Tanaka, Hiroshi Yoshida, Naobumi Tochigi, Yoshio Suzuki, Tadahiro Oonishi, Hidenori Tani, Keiko Tano, Kenichi Ijiri …

PLOS ONE, 7(4) e34949, Apr, 2012 Peer-reviewedLead author

Misc.

ノンコーティングRNAによるエピジェネティクスの制御ストレス応答における核内長鎖ノンコーディングRNAの働き(Epigenetic regulation by non-coding RNAs Functions of nuclear long noncoding RNAs in stress responses)

秋光信佳, 小野口玲菜, 川村猛, Diederichs Sven, 鈴木穣

日本癌学会総会記事, 78回 IS12-4, Sep, 2019
Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals (vol 22, pg 947, 2012)

Hidenori Tani, Rena Mizutani, Kazi Abdus Salam, Keiko Tano, Kenichi Ijiri, Ai Wakamatsu, Takao Isogai, Yutaka Suzuki, Nobuyoshi Akimitsu

GENOME RESEARCH, 22(7) 1382-1382, Jul, 2012

Research Projects

局所的なRNAの量的制御による熱応答性核内構造体の形成維持機構と生理的意義の解析

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

小野口玲菜
Study of novel stress response mechanism in human cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
熱ストレス下における非コードRNA,MALAT1の生理的意義と機能ドメインの解明

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

小野口玲菜
Analysis of heat-response gene regulation through norvel nuclear body by containing the noncoding RNA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Onoguchi-Mizutani Rena
Functional analysis of lncRNAs regulating immune response

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Nobuyoshi Akimitsu
Identification of the components of heat-responsible novel nuclear body containing MALAT1, a long noncoding RNA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2016 - Mar, 2018

Onoguchi Rena