2021年2月8日
Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation.
Nature communications
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- 巻
- 12
- 号
- 1
- 開始ページ
- 863
- 終了ページ
- 863
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41467-021-21160-0
- 出版者・発行元
- Nature research
A concept of polyclonal metastasis has recently been proposed, wherein tumor cell clusters break off from the primary site and are disseminated. However, the involvement of driver mutations in such polyclonal mechanism is not fully understood. Here, we show that non-metastatic AP cells metastasize to the liver with metastatic AKTP cells after co-transplantation to the spleen. Furthermore, AKTP cell depletion after the development of metastases results in the continuous proliferation of the remaining AP cells, indicating a role of AKTP cells in the early step of polyclonal metastasis. Importantly, AKTP cells, but not AP cells, induce fibrotic niche generation when arrested in the sinusoid, and such fibrotic microenvironment promotes the colonization of AP cells. These results indicate that non-metastatic cells can metastasize via the polyclonal metastasis mechanism using the fibrotic niche induced by malignant cells. Thus, targeting the fibrotic niche is an effective strategy for halting polyclonal metastasis.
- リンク情報
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- DOI
- https://doi.org/10.1038/s41467-021-21160-0
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/33558489
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870854
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000625204500018&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85101172847&partnerID=MN8TOARS
- ID情報
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- DOI : 10.1038/s41467-021-21160-0
- ISSN : 2041-1723
- ORCIDのPut Code : 104395739
- PubMed ID : 33558489
- PubMed Central 記事ID : PMC7870854
- SCOPUS ID : 85101172847
- Web of Science ID : WOS:000625204500018