MISC

2016年2月

Influence of smoking on perioperative oxidative stress after pulmonary resection

SURGERY TODAY
  • Yoshimasa Mizuno
  • ,
  • Hisashi Iwata
  • ,
  • Hirotaka Yamamoto
  • ,
  • Yusaku Miyamoto
  • ,
  • Shohei Mitta
  • ,
  • Koyo Shirahashi
  • ,
  • Hirofumi Takemura

46
2
開始ページ
183
終了ページ
187
記述言語
英語
掲載種別
DOI
10.1007/s00595-015-1132-4
出版者・発行元
SPRINGER

Purpose We herein investigated the influence of smoking on changes in the levels of perioperative oxidative stress after pulmonary resection.
Methods A total of 31 patients with primary lung cancer who underwent curative pulmonary lobectomy were analyzed prospectively. The degree of perioperative oxidative stress was evaluated based on the serum levels of derivatives of reactive oxygen metabolites (d-ROM) and biological antioxidant potential (BAP). The patients were divided into two groups: group A (smoking < 40 pack-years) and group B (smoking < 40 pack-years). The d-ROM and BAP measurements were obtained preoperatively, postoperatively and on the first, second, third and fifth postoperative days.
Results In all 31cases, the d-ROM values were higher on the third and fifth postoperative days than preoperatively. The extent of change in the d-ROM levels was greater in group A than in group B on the second, third and fifth postoperative days (1.05 +/- 0.159 vs. 0.920 +/- 0.205, p = 0.008; 1.20 +/- 0.233 vs. 1.02 +/- 0.186, p = 0.032; 1.34 +/- 0.228 vs. 1.07 +/- 0.200, p = 0.003, respectively). In contrast, there were no significant differences in the BAP values. The maximum increase in the d-ROM level and decrease in the BAP level negatively correlated with the amount of smoking (|r| = 0.428, p = 0.016 and |r| = 0.357. p = 0.049, respectively).
Conclusions Surgical stress associated with pulmonary lobectomy induces oxidative stress. In addition, smoking reduces the oxidative stress reaction, and the degree of this change is correlated with the amount of smoking.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1007/s00595-015-1132-4
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000369915000007&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84955345624&origin=inward
ID情報
  • DOI : 10.1007/s00595-015-1132-4
  • ISSN : 0941-1291
  • eISSN : 1436-2813
  • SCOPUS ID : 84955345624
  • Web of Science ID : WOS:000369915000007

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