Several retinal diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy, are partly caused by vascular endothelial growth factor (VEGF)-induced angiogenesis. Recently, anti-VEGF drugs, such as pegaptanib, ranibizumab, and aflibercept, have been used as clinical treatments. However, current anti-VEGF drugs do not have sufficient efficacy to be used as effective therapies for the aforementioned retinal diseases; therefore, the development of more effective novel drugs is needed. Dietary supplements have been shown to be efficacious in the prophylactic treatment of retinal diseases. We previously showed that anthocyaninrich foods such as bilberry, purple rice, and maqui berry possess preventative effects when tested in various retinal disease models. In this chapter, we discuss the effects of anthocyanin-rich foods in retinal disease models and their potential for clinical applications.