2012年12月
Spi-B is critical for plasmacytoid dendritic cell function and development
BLOOD
- 巻
- 120
- 号
- 24
- 開始ページ
- 4733
- 終了ページ
- 4743
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1182/blood-2012-06-436527
- 出版者・発行元
- AMER SOC HEMATOLOGY
Plasmacytoid dendritic cells (pDCs), originating from hematopoietic progenitor cells in the BM, are a unique dendritic cell subset that can produce large amounts of type I IFNs by signaling through the nucleic acid-sensing TLR7 and TLR9 (TLR7/9). The molecular mechanisms for pDC function and development remain largely unknown. In the present study, we focused on an Ets family transcription factor, Spi-B, that is highly expressed in pDCs. Spi-B could transactivate the type I IFN promoters in synergy with IFN regulatory factor 7 (IRF-7), which is an essential transcription factor for TLR7/9-induced type I IFN production in pDCs. Spi-B-deficient pDCs and mice showed defects in TLR7/9-induced type I IFN production. Furthermore, in Spi-B-deficient mice, BM pDCs were decreased and showed attenuated expression of a set of pDC-specific genes whereas peripheral pDCs were increased; this uneven distribution was likely because of defective retainment of mature nondividing pDCs in the BM. The expression pattern of cell-surface molecules in Spi-B-deficient mice indicated the involvement of Spi-B in pDC development. The developmental defects of pDCs in Spi-B-deficient mice were more prominent in the BM than in the peripheral lymphoid organs and were intrinsic to pDCs. We conclude that Spi-B plays critical roles in pDC function and development. (Blood. 2012;120(24):4733-4743)
- リンク情報
-
- DOI
- https://doi.org/10.1182/blood-2012-06-436527
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000313115300015&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84870736373&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0003-0493-4815
- ID情報
-
- DOI : 10.1182/blood-2012-06-436527
- ISSN : 0006-4971
- ORCIDのPut Code : 22666708
- SCOPUS ID : 84870736373
- Web of Science ID : WOS:000313115300015