2017年5月
Octacalcium phosphate collagen composite facilitates bone regeneration of large mandibular bone defect in humans
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- ,
- ,
- ,
- ,
- ,
- 巻
- 11
- 号
- 5
- 開始ページ
- 1641
- 終了ページ
- 1647
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/term.2110
- 出版者・発行元
- WILEY
Recently it was reported that the implantation of octacalcium phosphate (OCP) and collagen composite (OCP-collagen) was effective at promoting bone healing in small bone defects after cystectomy in humans. In addition, OCP-collagen promoted bone regeneration in a critical-sized bone defect of a rodent or canine model. In this study, OCP-collagen was implanted into a human mandibular bone defect with a longer axis of approximately 40 mm, which was diagnosed as a residual cyst with apical periodontitis. The amount of OCP-collagen implanted was about five times greater than the amounts implanted in previous clinical cases. Postoperative wound healing was satisfactory and no infection or allergic reactions occurred. The OCP-collagen-treated lesion was gradually filled with radio-opaque figures, and the alveolar region occupied the whole of the bone defect 12 months after implantation. This study suggests that OCP-collagen could be a useful bone substitute material for repairing large bone defects in humans that might not heal spontaneously. Copyright (C) 2015 John Wiley & Sons, Ltd.
- リンク情報
- ID情報
-
- DOI : 10.1002/term.2110
- ISSN : 1932-6254
- eISSN : 1932-7005
- Web of Science ID : WOS:000402987500030