2010年6月
Biochemical Target Isolation for Novices: Affinity-Based Strategies
CHEMISTRY & BIOLOGY
- ,
- ,
- ,
- 巻
- 17
- 号
- 6
- 開始ページ
- 616
- 終了ページ
- 623
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.chembiol.2010.05.015
- 出版者・発行元
- CELL PRESS
Although a number of genomic and biochemical technologies are now used to elucidate the mechanisms of action of bioactive small molecules, affinity-based isolation of molecular targets is a classic, but still powerful, approach. This review highlights recent cases where biochemical isolation of target proteins of bioactive small molecules highlighted general strategies for a successful isolation and identification of molecular targets. This review is intended to be both an update on the most recent findings for those already active in the field of forward chemical genetics and a guide for scientists entering this burgeoning field.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.chembiol.2010.05.015
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201102219002837368
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20609411
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279616700009&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.chembiol.2010.05.015
- ISSN : 1074-5521
- J-Global ID : 201102219002837368
- PubMed ID : 20609411
- Web of Science ID : WOS:000279616700009