2019年12月1日
Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model
Nature Communications
- 巻
- 10
- 号
- 1
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41467-019-12232-3
- 出版者・発行元
- Springer Science and Business Media {LLC}
© 2019, The Author(s). The pathway of homeostatic IgG extravasation is not fully understood, in spite of its importance for the maintenance of host immunity, the management of autoantibody-mediated disorders, and the use of antibody-based biologics. Here we show in a murine model of pemphigus, a prototypic cutaneous autoantibody-mediated disorder, that blood-circulating IgG extravasates into the skin in a time- and dose-dependent manner under homeostatic conditions. This IgG extravasation is unaffected by depletion of Fcγ receptors, but is largely attenuated by specific ablation of dynamin-dependent endocytic vesicle formation in blood endothelial cells (BECs). Among dynamin-dependent endocytic vesicles, IgG co-localizes well with caveolae in cultured BECs. An Abl family tyrosine kinase inhibitor imatinib, which reduces caveolae-mediated endocytosis, impairs IgG extravasation in the skin and attenuates the murine pemphigus manifestations. Our study highlights the kinetics of IgG extravasation in vivo, which might be a clue to understand the pathological mechanism of autoantibody-mediated autoimmune disorders.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41467-019-12232-3
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31570755
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072763361&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85072763361&origin=inward
- ID情報
-
- DOI : 10.1038/s41467-019-12232-3
- eISSN : 2041-1723
- ORCIDのPut Code : 95981317
- PubMed ID : 31570755
- SCOPUS ID : 85072763361