Sep, 2015
Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice
FEBS LETTERS
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- Volume
- 589
- Number
- 19
- First page
- 2805
- Last page
- 2811
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/j.febslet.2015.08.024
- Publisher
- ELSEVIER SCIENCE BV
JNK/stress-activated protein kinase-associated protein 1 (JSAP1) and JNK-associated leucine zipper protein (JLP) are structurally related scaffolding proteins that are highly expressed in the brain. Here, we found that JSAP1 and JLP play functionally redundant and essential roles in mouse cerebellar Purldnje cell (PC) survival. Mice containing PCs with deletions in both JSAP1 and JLP exhibited PC axonal dystrophy, followed by gradual, progressive neuronal loss. Kinesin-1 cargoes accumulated selectively in the swollen axons of Jsap1/Jlp-deficient PCs. In addition, autophagy inactivation in these mice markedly accelerated PC degeneration. These findings suggest that JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport, which prevents brain neuronal degeneration. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- Link information
- ID information
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- DOI : 10.1016/j.febslet.2015.08.024
- ISSN : 0014-5793
- eISSN : 1873-3468
- Pubmed ID : 26320416
- Web of Science ID : WOS:000362619700022