2011年7月
New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status
BRAIN TUMOR PATHOLOGY
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- 巻
- 28
- 号
- 3
- 開始ページ
- 203
- 終了ページ
- 208
- 記述言語
- 英語
- 掲載種別
- 書評論文,書評,文献紹介等
- DOI
- 10.1007/s10014-011-0050-4
- 出版者・発行元
- SPRINGER JAPAN KK
In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.
- リンク情報
- ID情報
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- DOI : 10.1007/s10014-011-0050-4
- ISSN : 1433-7398
- Web of Science ID : WOS:000293533300006