2022年1月
Experimental and Mouse-Specific Computational Models of the Fbln4 Mouse to Identify Potential Biomarkers for Ascending Thoracic Aortic Aneurysm
Cardiovascular engineering and technology
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- Epub
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- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s13239-021-00600-4
- 出版者・発行元
- SPRINGER
[PURPOSE] To use computational methods to explore geometric, mechanical, and fluidic biomarkers that could correlate with mouse lifespan in the Fbln4 mouse. Mouse lifespan was used as a surrogate for risk of a severe cardiovascular event in cases of ascending thoracic aortic aneurysm.
[METHODS] Image-based, mouse-specific fluid-structure-interaction models were developed for Fbln4 mice (n = 10) at ages two and six months. The results of the simulations were used to quantify potential biofluidic biomarkers, complementing the geometrical biomarkers obtained directly from the images.
[RESULTS] Comparing the different geometrical and biofluidic biomarkers to the mouse lifespan, it was found that mean oscillatory shear index (OSI) and minimum time-averaged wall shear stress (TAWSS) at six months showed the largest correlation with lifespan (r = 0.70, 0.56), with both correlations being positive (i.e., mice with high OSI and high TAWSS tended to live longer). When change between two and six months was considered, the change in TAWSS showed a much stronger correlation than OSI (r = 0.75 vs. 0.24), and the correlation was negative (i.e., mice with increasing TAWSS over this period tended to live less long).
[CONCLUSION] The results highlight potential biomarkers of ATAA outcomes that can be obtained through noninvasive imaging and computational simulations, and they illustrate the potential synergy between small-animal and computational models.
[METHODS] Image-based, mouse-specific fluid-structure-interaction models were developed for Fbln4 mice (n = 10) at ages two and six months. The results of the simulations were used to quantify potential biofluidic biomarkers, complementing the geometrical biomarkers obtained directly from the images.
[RESULTS] Comparing the different geometrical and biofluidic biomarkers to the mouse lifespan, it was found that mean oscillatory shear index (OSI) and minimum time-averaged wall shear stress (TAWSS) at six months showed the largest correlation with lifespan (r = 0.70, 0.56), with both correlations being positive (i.e., mice with high OSI and high TAWSS tended to live longer). When change between two and six months was considered, the change in TAWSS showed a much stronger correlation than OSI (r = 0.75 vs. 0.24), and the correlation was negative (i.e., mice with increasing TAWSS over this period tended to live less long).
[CONCLUSION] The results highlight potential biomarkers of ATAA outcomes that can be obtained through noninvasive imaging and computational simulations, and they illustrate the potential synergy between small-animal and computational models.
- ID情報
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- DOI : 10.1007/s13239-021-00600-4
- ISSN : 1869-4098