2019年11月
Distinct effects of orexin receptor antagonist and GABA agonist on sleep and physical/cognitive functions after forced awakening
Proceedings of the National Academy of Sciences of the United States of America
- 巻
- 116
- 号
- 48
- 開始ページ
- 24353
- 終了ページ
- 24358
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1073/pnas.1907354116
- 出版者・発行元
- NATL ACAD SCIENCES
The majority of patients with insomnia are treated with hypnotic agents. In the present study, we evaluated the side-effect profile of an orexin receptor antagonist and γ-aminobutyric acid A (GABA) receptor agonist on physical/cognitive functions upon forced awakening. This double-blind, randomized, placebo-controlled, cross-over study was conducted on 30 healthy male subjects. Fifteen minutes before bedtime, the subjects took a pill of suvorexant (20 mg), brotizolam (0.25 mg), or placebo and were forced awake 90 min thereafter. Physical- and cognitive-function tests were performed before taking the pill, after forced awakening, and the next morning. Polysomnographic recordings revealed that the efficacies of the hypnotic agents in prolonging total sleep time (∼30 min) and increasing sleep efficiency (∼6%) were comparable. When the subjects were allowed to go back to sleep after the forced awakening, the sleep latency was shorter under the influence of hypnotic agents (∼2 min) compared to the placebo trial (24 min), and the rapid eye movement latency was significantly shorter under suvorexant (98.8, 81.7, and 48.8 min for placebo, brotizolam, and suvorexant, respectively). A
- リンク情報
- ID情報
-
- DOI : 10.1073/pnas.1907354116
- ISSN : 1091-6490
- PubMed ID : 31712421
- PubMed Central 記事ID : PMC6883838