論文

査読有り
2017年7月

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results

INORGANIC CHEMISTRY
  • Amandine Boulmier
  • ,
  • Xinxin Feng
  • ,
  • Olivier Oms
  • ,
  • Pierre Mialane
  • ,
  • Eric Riviere
  • ,
  • Christopher J. Shin
  • ,
  • Jiaqi Yao
  • ,
  • Tadahiko Kubo
  • ,
  • Taisuke Furuta
  • ,
  • Eric Oldfield
  • ,
  • Anne Dolbecq

56
13
開始ページ
7558
終了ページ
7565
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.inorgchem.7b01114
出版者・発行元
AMER CHEMICAL SOC

We synthesized a series of polyoxometalatebisphosphonate complexes containing Mov106 octahedra, zoledronate, or an N-alkyl (n-C-6 or n-C-8) zoledronate analogue, and in two cases, Mn as a heterometal. Mo6L2 (L = Zol, ZolC(6), ZolC(8)) and MO4L2Mn = Zol, ZolC(8)) were characterized by using single-crystal X-ray crystallography and/or IR spectroscopy, elemental and energy dispersive X-ray analysis and P-31 NMR. We found promising activity against human nonsmall cell lung cancer (NCI-H460) cells with IC50 values for growth inhibition of 5 fiM per bisphosphonate ligand. The effects of bisphosphonate complexation on IC50 decreased with increasing bisphosphonate chain length: C-0 approximate to 6.1x, C-6 approximate to 3.4x, and C8 approximate to 1.1x. We then determined the activity of One of the most potent compounds in the series, Mo(4)Zol(2)Mn(III), against SK-ES-1 sarcoma cells in a mouse xenograft system finding a similar to 5x decrease in tumor volume than found with the parent compound zoledronate at the same compound dosing, (5 mu g/mouse). Overall, the, results are of interest since we show for the first time that heteropolyoxomolybdate-bisphosphonate hybrids kill tumor cells in vitro and significantly decrease tumor growth) in-vivo, opening up new possibilities for targeting both Ras as, well as epidermal growth factor receptor driyen cancers.

Web of Science ® 被引用回数 : 16

リンク情報
DOI
https://doi.org/10.1021/acs.inorgchem.7b01114
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000405056400029&DestApp=WOS_CPL