2017年12月
A polyrotaxane gel using boronic acid-appended γ-cyclodextrin as a hybrid cross-linker
Journal of Inclusion Phenomena and Macrocyclic Chemistry
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 89
- 号
- 3-4
- 開始ページ
- 281
- 終了ページ
- 288
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s10847-017-0755-z
A boronic acid-appended γ-cyclodextrin (BA-CyD) was synthesized as a hybrid cross-linker of polyvinyl alcohol (PVA) to form a new type of hydrogel. The CyD moiety of BA-CyD forms an inclusion complex with the PVA chain to produce a mechanically interlocking structure. At the same time, the BA moiety of BA-CyD forms covalent bonds with the 1,3-diol moieties of PVA. On the basis of these two modes of interaction, the hybrid cross-linker connects two PVA chains, thus resulting in the formation of a hydrogel. To investigate the possibility of this hydrogel becoming the basis for an intelligent material for drug delivery, sugar-responsive drug release from the hydrogel was demonstrated.
- リンク情報
- ID情報
-
- DOI : 10.1007/s10847-017-0755-z
- ISSN : 1388-3127
- eISSN : 1573-1111
- Web of Science ID : WOS:000414694500006