2017年6月
In vitro evaluation of Ag-containing calcium phosphates: Effectiveness of Ag-incorporated beta-tricalcium phosphate
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
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- 巻
- 75
- 号
- 開始ページ
- 926
- 終了ページ
- 933
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.msec.2017.02.059
- 出版者・発行元
- ELSEVIER SCIENCE BV
Development of bioceramics with antibacterial activity and without cytotoxicity would be beneficial for preventing infection associated with implants. This study aimed to capitalize on the antibacterial properties of silver (Ag) incorporated in or coexisting in metallic form with calcium phosphates (CaPs). The in vitro dissolution behavior, antibacterial activity, and cytotoxicity of Ag-containing CaPs with different phase fractions of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) were evaluated. The antibacterial activity of Ag-containing CaPs depended on the main phase of CaP), the chemical state of Ag, and the amount of incorporated Ag. Superior antibacterial activity was obtained from sustained release of Ag ions through continuous dissolution of Ag-incorporated beta-TCP compared to that obtained for HA coexisting with metallic Ag particles. Ag-containing CaPs did not exhibit any toxic effect on V79 fibroblasts. Thus, these results demonstrated the effectiveness of Ag-incorporated beta-TCP in preventing infection, with respect to long-term applications. (C) 2017 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.msec.2017.02.059
- ISSN : 0928-4931
- eISSN : 1873-0191
- PubMed ID : 28415548
- Web of Science ID : WOS:000400720800107