1996年11月12日
The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists.
Cancer letters
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- 巻
- 108
- 号
- 1
- 開始ページ
- 1
- 終了ページ
- 5
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.
- リンク情報
- ID情報
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- ISSN : 0304-3835
- PubMed ID : 8950202