1994年1月
ALTERNATIVE 5' SPLICE-SITE SELECTION INDUCED BY HEAT-SHOCK
MOLECULAR AND CELLULAR BIOLOGY
- ,
- ,
- ,
- 巻
- 14
- 号
- 1
- 開始ページ
- 567
- 終了ページ
- 575
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- AMER SOC MICROBIOLOGY
The mouse HSP47 gene consists of six exons separated by five introns. Three HSP47 cDNAs differing only in their 5' noncoding regions have been reported. One of these alternatively spliced mRNAs was detected only after heat shock, which caused an alternative 5' splice donor site selection. Other stress inducers, including an amino acid analog and sodium arsenite, had no effect on the alternative splicing. The alternatively spliced mRNA, which was 169 nucleotides longer in the 5' noncoding region compared to mRNA transcribed in non-heat shock conditions, was efficiently translated under heat shock conditions. This novel finding that alternative splicing is caused by artificial treatment like heat shock will provide a useful in vivo model for understanding the exon-intron recognition mechanism as well as heat shock-induced alterations in gene expression.
- リンク情報
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- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902163095660329
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/8264624
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994MM98100057&DestApp=WOS_CPL
- ID情報
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- ISSN : 0270-7306
- J-Global ID : 200902163095660329
- PubMed ID : 8264624
- Web of Science ID : WOS:A1994MM98100057